Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, WA, USA.
Division of Occupational Therapy, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Sci Prog. 2024 Jul-Sep;107(3):368504241263692. doi: 10.1177/00368504241263692.
Examination of the variability of stress biomarkers among people living with dementia and their family caregivers can provide evidence of stress reactions and corresponding self-regulation capacities, but no such research has been conducted to date. The aim of this study was to examine day-to-day variability patterns of salivary biomarkers in dyads of people living with dementia and their family caregivers and to investigate differences in variability patterns between music intervention and control groups. This study involved secondary analysis of data collected during a two-group, non-randomized open trial examining the effects of an 8-week music intervention on physiological stress markers. A total of 5791 salivary samples from 34 dyads were used to analyze the variability of morning and evening cortisol and of morning dehydroepiandrosterone sulfate (DHEA-S). The variability indices employed were the intra- and inter-individual standard deviation, coefficient of variation, and intra-class correlation coefficient. We found that family caregivers in the music intervention group had significantly greater coefficients of variation for all three biomarker endpoints than those in the control group. Our findings provide evidence that stress biomarkers in family caregivers with functional self-regulation capacities may be more likely to respond to music intervention. However, stress biomarkers in people living with dementia may not be responsive to music intervention, possibly due to their dysfunctional self-regulation capacities. Future stress biomarker studies involving dyads of people living with dementia and family caregivers should consider biomarker variability patterns in determining the effectiveness of behavioral interventions.
对患有痴呆症的患者及其家庭照顾者的应激生物标志物的变异性进行检查，可以提供应激反应和相应的自我调节能力的证据，但迄今为止，尚未对此进行研究。本研究旨在检查痴呆症患者及其家庭照顾者的唾液生物标志物的日常变异性模式，并调查音乐干预组和对照组之间的变异性模式差异。本研究是对一项为期 8 周的音乐干预对生理应激标志物影响的双组、非随机开放试验中收集的数据进行的二次分析。共分析了 34 对 2 组中 5791 份唾液样本，以分析清晨和傍晚皮质醇以及清晨脱氢表雄酮硫酸盐（DHEA-S）的变异性。所使用的变异性指标包括个体内和个体间标准差、变异系数和组内相关系数。我们发现，音乐干预组的家庭照顾者在所有三个生物标志物终点的变异系数均明显大于对照组。我们的研究结果表明，具有功能性自我调节能力的家庭照顾者的应激生物标志物可能更容易对音乐干预产生反应。然而，患有痴呆症的患者的应激生物标志物可能对音乐干预没有反应，这可能是由于他们的自我调节能力失调所致。未来涉及痴呆症患者及其家庭照顾者的双体应激生物标志物研究应考虑生物标志物变异性模式，以确定行为干预的有效性。
