Trifonov E N
CRC Crit Rev Biochem. 1985;19(2):89-106. doi: 10.3109/10409238509082540.
A priori considerations and the concept of the sequence-dependent local curving of the DNA axis. Experimental evidence: electric dichroism (relaxation time measurements); anomalous electrophoretic mobility and gel-filtration of some restriction fragments of DNA; one-sided binding of the nucleosomal DNA to the mica surface. Theoretical predictions concerning the nucleotide sequences of the curved DNA. Discovery of the dinucleotide periodicity in the chromatin DNA. The sequence periodicity as a tool for mapping of the nucleosomes along the sequences. Preferential binding of the histone octamers to the curved pieces of DNA--sequence analysis predictions and comparison with experiments: Theoretical and experimental estimates of the tilt and roll angles for different combinations of the neighboring base-pairs. Inherent sequence-dependent curvature and apparent persistence length of DNA.
先验考虑因素以及DNA轴序列依赖性局部弯曲的概念。实验证据：电二色性（弛豫时间测量）；DNA某些限制性片段的异常电泳迁移率和凝胶过滤；核小体DNA与云母表面的单侧结合。关于弯曲DNA核苷酸序列的理论预测。染色质DNA中二核苷酸周期性的发现。序列周期性作为沿序列定位核小体的工具。组蛋白八聚体与DNA弯曲片段的优先结合——序列分析预测及与实验的比较：不同相邻碱基对组合的倾斜角和滚动角的理论与实验估计。DNA固有的序列依赖性曲率和表观持久长度。
