Reply to Xiao and Galstyan: Reliable ligand discrimination involves many trade-offs.
作者信息
Kirby Duncan
机构信息
Department of Physics, University of Toronto, Toronto, ON, M5S 1A7, Canada.
出版信息
Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2411465121. doi: 10.1073/pnas.2411465121. Epub 2024 Jul 25.
Abstract
摘要
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本文引用的文献
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With the leisure of time, kinetic proofreading can still perform reliable ligand discrimination.在有时间空闲的情况下，动力学校对仍能进行可靠的配体识别。
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Proofreading does not result in more reliable ligand discrimination in receptor signaling due to its inherent stochasticity.由于其固有的随机性，校对不会导致受体信号中配体的区分更可靠。
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