Post Graduate Department of Biotechnology, Utkal University, Bhubaneswar, Odisha 751004, India.
KIIT school of Biotechnology, KIIT University, Patia, Bhubaneswar, Odisha 751024, India.
Biomed Pharmacother. 2024 Sep;178:117177. doi: 10.1016/j.biopha.2024.117177. Epub 2024 Jul 24.
Cytokines regulate immune responses essential for maintaining immune homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge as promising therapeutic agents because they mitigate oxidative stress and modulate inflammatory pathways. Antioxidants can potentially ameliorate inflammation-related disorders by counteracting excessive cytokine-mediated inflammatory responses. A comprehensive understanding of cytokine-mediated inflammatory pathways and the interplay with antioxidants is paramount for developing natural therapeutic agents targeting inflammation-related disorders and helping to improve clinical outcomes and enhance the quality of life for patients. Among these antioxidants, curcumin, vitamin C, vitamin D, propolis, allicin, and cinnamaldehyde have garnered attention for their anti-inflammatory properties and potential therapeutic benefits. This review highlights the interrelationship between cytokines-mediated disorders in various diseases and therapeutic approaches involving antioxidants.
细胞因子调节对维持免疫稳态至关重要的免疫反应，因为细胞因子信号的失调可能导致有害的结果，包括炎症性疾病。抗氧化剂作为有前途的治疗剂出现，因为它们减轻氧化应激并调节炎症途径。抗氧化剂可以通过抵消过度的细胞因子介导的炎症反应，潜在地改善与炎症相关的疾病。全面了解细胞因子介导的炎症途径以及与抗氧化剂的相互作用对于开发针对炎症相关疾病的天然治疗剂至关重要，有助于改善临床结果并提高患者的生活质量。在这些抗氧化剂中，姜黄素、维生素 C、维生素 D、蜂胶、大蒜素和肉桂醛因其抗炎特性和潜在的治疗益处而受到关注。本综述强调了各种疾病中细胞因子介导的疾病与涉及抗氧化剂的治疗方法之间的相互关系。
