Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali, Yunnan, China.
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali, Yunnan, China; National-Local Joint. Engineering Research Center of Entomoceutics, Dali, Yunnan, China.
Biomed Pharmacother. 2024 Oct;179:117333. doi: 10.1016/j.biopha.2024.117333. Epub 2024 Sep 8.
Kidney stones, a prevalent urological disorder, are closely associated with oxidative stress (OS) and the inflammatory response. Recent research in the field of kidney stone treatment has indicated the potential of natural active ingredients to modulate OS targets and the inflammatory response in kidney stones. Oxidative stress can occur through various pathways, increasing the risk of stone formation, while the inflammatory response generated during kidney stone formation further exacerbates OS, forming a detrimental cycle. Both antioxidant systems related to OS and inflammatory mediators associated with inflammation play roles in the pathogenesis of kidney stones. Natural active ingredients, abundant in resources and possessing antioxidative and anti-inflammatory properties, have the ability to decrease the risk of stone formation and improve prognosis by reducing OS and suppressing pro-inflammatory cytokine expression or pathways. Currently, numerous developed natural active ingredients have been clinically applied and demonstrated satisfactory therapeutic efficacy. This review aims to provide novel insights into OS and inflammation targets in kidney stones as well as summarize research progress on potential therapeutic strategies involving natural active ingredients. Future studies should delve deeper into exploring efficacy and mechanisms of action of diverse natural active ingredients, proposing innovative treatment strategies for kidney stones, and continuously uncovering their potential applications.
肾结石是一种常见的泌尿系统疾病，与氧化应激（OS）和炎症反应密切相关。最近在肾结石治疗领域的研究表明，天然活性成分具有调节 OS 靶点和肾结石炎症反应的潜力。氧化应激可通过多种途径发生，增加结石形成的风险，而肾结石形成过程中产生的炎症反应进一步加剧 OS，形成恶性循环。与 OS 相关的抗氧化系统和与炎症相关的炎症介质都在肾结石的发病机制中发挥作用。天然活性成分资源丰富，具有抗氧化和抗炎特性，能够降低 OS 和抑制促炎细胞因子表达或途径，从而降低结石形成的风险，改善预后。目前，许多已开发的天然活性成分已在临床上应用，并表现出令人满意的治疗效果。本综述旨在为肾结石的 OS 和炎症靶点提供新的见解，并总结涉及天然活性成分的潜在治疗策略的研究进展。未来的研究应深入探讨不同天然活性成分的疗效和作用机制，为肾结石提出创新的治疗策略，并不断挖掘其潜在的应用。
