Howlett Jonathon R, Park Heekyeong, Paulus Martin P
VA San Diego Healthcare System, San Diego, California; Department of Psychiatry, University of California San Diego, La Jolla, California.
Laureate Institute for Brain Research, Tulsa, Oklahoma; Department of Psychology, University of North Texas at Dallas, Dallas, Texas.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jul 23. doi: 10.1016/j.bpsc.2024.07.010.
Posttraumatic stress disorder (PTSD) is characterized not only by its direct association with traumatic events but also by a potential deficit in inhibitory control across emotional, cognitive, and sensorimotor domains. Recent research has shown that a continuous sensorimotor feedback control task, the rapid assessment of motor processing paradigm, can yield reliable measures of individual sensorimotor control performance. This study used this paradigm to investigate control deficits in PTSD compared with both a healthy volunteer group and a non-PTSD psychiatric comparison group.
We examined control processing using the rapid assessment of motor processing paradigm in a sample of 40 individuals with PTSD, matched groups of 40 individuals with mood and anxiety complaints, and 40 healthy control participants. We estimated K (drive) and K (damping) parameters using a proportional-derivative control modeling approach.
The K parameter was lower in the PTSD group than in the healthy control (Cohen's d = 0.86) and mood and anxiety (Cohen's d = 0.63) groups. After controlling for color-word inhibition, K remained lower in the PTSD group than in the healthy control (Cohen's d = 0.79) and mood and anxiety (Cohen's d = 0.62) groups. Mediation analysis showed that K significantly mediated the relationship between PTSD and control deficits in the K parameter, with 96% of the effect being mediated by K.
These findings underscore the potential of using dynamic control paradigms to elucidate the control dysfunctions in PTSD and suggest that different psychiatric conditions may distinctly influence subcomponents of sensorimotor control.
创伤后应激障碍（PTSD）的特征不仅在于其与创伤事件的直接关联，还在于情绪、认知和感觉运动领域抑制控制方面可能存在的缺陷。最近的研究表明，一种连续的感觉运动反馈控制任务，即运动处理范式的快速评估，可以产生个体感觉运动控制性能的可靠测量值。本研究使用该范式，将PTSD患者与健康志愿者组和非PTSD精神疾病对照组进行比较，以调查PTSD中的控制缺陷。
我们使用运动处理范式的快速评估来检查40名PTSD患者、40名有情绪和焦虑主诉的匹配个体组以及40名健康对照参与者的控制处理情况。我们使用比例-微分控制建模方法估计K（驱动）和K（阻尼）参数。
PTSD组的K参数低于健康对照组（Cohen's d = 0.86）以及情绪和焦虑组（Cohen's d = 0.63）。在控制了颜色-单词抑制后，PTSD组的K参数仍低于健康对照组（Cohen's d = 0.79）以及情绪和焦虑组（Cohen's d = 0.62）。中介分析表明，K显著中介了PTSD与K参数控制缺陷之间的关系，其中96%的效应由K介导。
这些发现强调了使用动态控制范式来阐明PTSD中控制功能障碍的潜力，并表明不同的精神疾病可能对感觉运动控制的子成分产生不同的影响。
