Macrophages and Endothelial Cells Unit, Department of Developmental and Stem Cell Biology, Institut Pasteur, Université Paris Cité, Paris, France; Sorbonne Université, Collège Doctoral, Paris, France.
Macrophages and Endothelial Cells Unit, Department of Developmental and Stem Cell Biology, Institut Pasteur, Université Paris Cité, Paris, France.
Exp Hematol. 2024 Aug;136:104285. doi: 10.1016/j.exphem.2024.104285. Epub 2024 Jul 23.
The first blood and immune cells in vertebrates emerge in the extraembryonic yolk sac. Throughout the last century, it has become evident that this extraembryonic tissue gives rise to transient primitive and definitive hematopoiesis but not hematopoietic stem cells. More recently, studies have elucidated that yolk sac-derived blood and immune cells are present far longer than originally expected. These cells take over essential roles for the survival and proper organogenesis of the developing fetus up until birth. In this review, we discuss the most recent findings and views on extraembryonic hematopoiesis in mice and humans.
脊椎动物的第一批血液和免疫细胞出现在胚外卵黄囊中。在上个世纪，很明显，这种胚外组织会产生短暂的原始和确定的造血作用，但不会产生造血干细胞。最近的研究表明，蛋黄囊衍生的血液和免疫细胞的存在时间远比最初预期的要长得多。这些细胞在出生前，为发育中胎儿的生存和适当器官发生发挥着至关重要的作用。在这篇综述中，我们讨论了关于小鼠和人类胚外造血的最新发现和观点。
