白血病发展过程中克隆进化、分化层次和个体发生的交叉点
The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development.
作者信息
Sturgeon Christopher M, Wagenblast Elvin, Izzo Franco, Papapetrou Eirini P
机构信息
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, New York.
Black Family Stem Cell Institute, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
出版信息
Blood Cancer Discov. 2025 Mar 4;6(2):94-109. doi: 10.1158/2643-3230.BCD-24-0235.
In recent years, remarkable technological advances have illuminated aspects of the pathogenesis of myeloid malignancies-yet outcomes for patients with these devastating diseases have not significantly improved. We posit that a synthesized view of the three dimensions through which hematopoietic cells transit during their healthy and diseased life-clonal evolution, stem cell hierarchy, and ontogeny-promises high yields in new insights into disease pathogenesis and new therapeutic avenues.
近年来，显著的技术进步揭示了髓系恶性肿瘤发病机制的各个方面——然而，患有这些毁灭性疾病的患者的治疗结果并未得到显著改善。我们认为，对造血细胞在其健康和患病生命过程中所经历的三个维度——克隆进化、干细胞层级结构和个体发生——进行综合考量，有望为疾病发病机制的新见解和新治疗途径带来丰硕成果。
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