Daude Matheus Martins, Manuli Erika Regina, Pereira Geovana Maria, Junior Alfredo Ramon Alfonso Cavalcante, de Souza Ueric José Borges, de Araujo Gessi Carvalho, de Pádua Milagres Flávio Augusto, Sabino Ester Cerdeira, Barreto Horllys Gomes
Universidade Federal do Tocantins, Faculdade de Medicina, Laboratório de Análise Molecular, Departamento de Ciências da Vida, Palmas, TO, Brazil.
Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical, São Paulo, SP, Brazil.
Braz J Infect Dis. 2024 Jul-Aug;28(4):103855. doi: 10.1016/j.bjid.2024.103855. Epub 2024 Jul 22.
In Brazil, Dengue, Zika and Chikungunya viruses constitute a major threat to the public health system. Simultaneous circulation of these arboviruses occurs in many regions of the world due to the expansion of transmission vectors. The infection by these arboviruses triggers similar symptoms during their acute phase. However, in some cases, severe symptoms may occur, leading to different types of disabilities and even death. In this context, considering the similarity of the symptoms, the problems caused by the infection of these arboviruses, and the increasing risk of coinfection in humans, the differential diagnosis of these infections is essential for clinical management and epidemiological investigation. Thus, this study aimed to identify, through diagnosis via Quantitative Polymerase Chain Reaction with Reverse Transcription, arbovirus coinfection in patients from the Tocantins state (Northern Brazil). A total of 495 samples were analyzed, three from which were determined to be a coinfection of Dengue and Chikungunya viruses. The data obtained here indicate the co-circulation and coinfection by Dengue and Chikungunya viruses in the Tocantins state. These results highlight the importance of monitoring the circulation of these arboviruses for the development of health actions that aim their prevention and combat, as well as their clinical and therapeutic management.
在巴西，登革热病毒、寨卡病毒和基孔肯雅病毒对公共卫生系统构成重大威胁。由于传播媒介的扩散，这些虫媒病毒在世界许多地区同时传播。这些虫媒病毒感染在急性期会引发相似症状。然而，在某些情况下，可能会出现严重症状，导致不同类型的残疾甚至死亡。在此背景下，考虑到症状的相似性、这些虫媒病毒感染所引发的问题以及人类同时感染的风险不断增加，对这些感染进行鉴别诊断对于临床管理和流行病学调查至关重要。因此，本研究旨在通过逆转录定量聚合酶链反应诊断，确定来自巴西北部托坎廷斯州患者中的虫媒病毒同时感染情况。共分析了495份样本，其中三份被确定为登革热病毒和基孔肯雅病毒的同时感染。此处获得的数据表明，登革热病毒和基孔肯雅病毒在托坎廷斯州共同传播且存在同时感染情况。这些结果凸显了监测这些虫媒病毒传播对于制定旨在预防、抗击以及进行临床和治疗管理的卫生行动的重要性。
