Uchida K, Takahashi M, Yoshida M, Shigemura M, Funabashi H, Fujiwara H
Jikken Dobutsu. 1985 Jul;34(3):277-85. doi: 10.1538/expanim1978.34.3_277.
Eight small obese mice, 10 to 79 weeks of age, which occurred in C57BL/6J obese mice, were examined clinico-pathologically. These mice were characterized by small-sized obesity, and showed hyperglycemia without hyperinsulinemia and glucosuria without ketonurina throughout their life span. Morphologically, neither hypertrophy nor hyperplasia were found in the islets of Langerhans. There were an increase of A cells and a decrease of B cells in their islets. In the kidney, thickening of mesangial matrix in glomeruli and deposition of glycogen in the nucleus of epithelial cells of the distal tubules were seen. These findings suggest that the small obese mice are an obese-diabetic animal of different type from the usual obese mice (C57BL/6J-ob/ob). The mechanism for development of this condition was unknown.
对8只10至79周龄、出现在C57BL/6J肥胖小鼠中的小型肥胖小鼠进行了临床病理检查。这些小鼠的特征是小型肥胖，在其整个寿命期间均表现出高血糖但无高胰岛素血症，以及糖尿但无酮尿。形态学上，胰岛中未发现肥大或增生。其胰岛中A细胞增加，B细胞减少。在肾脏中，可见肾小球系膜基质增厚以及远端肾小管上皮细胞核内糖原沉积。这些发现表明，小型肥胖小鼠是一种与普通肥胖小鼠（C57BL/6J-ob/ob）不同类型的肥胖糖尿病动物。这种情况的发病机制尚不清楚。
