乳酸/乳酰化在眼部发育和疾病中的作用
Lactate/lactylation in ocular development and diseases.
作者信息
Chai Peiwei, Zhao Fei, Jia Renbing, Zhou Xiangtian, Fan Xianqun
机构信息
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, People's Republic of China.
State Key Laboratory of Ophthalmology, Optometry, and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou 325101, Zhejiang, China.
出版信息
Trends Mol Med. 2024 Jul 24. doi: 10.1016/j.molmed.2024.07.001.
Lactylation, a post-translational modification (PTM) induced by lactate, has crucial roles in the regulation of transcription, DNA repair, and mitochondrial metabolism. Here, we discuss the role of lactate/lactylation signaling in regulating eye morphogenesis and retinal homeostasis, as well as various ophthalmic disorders, such as myopia, intraocular malignancies, and retinal angiogenesis.
乳酰化是一种由乳酸诱导的翻译后修饰（PTM），在转录调控、DNA修复和线粒体代谢中发挥着关键作用。在此，我们讨论乳酸/乳酰化信号在调节眼睛形态发生和视网膜稳态以及各种眼科疾病（如近视、眼内恶性肿瘤和视网膜血管生成）中的作用。
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