Delfini C, Polchi P, Izzi T, Nicolini G, Paradisi O, Lucarelli G
Exp Hematol. 1985 Dec;13(11):1197-200.
This report describes the successful bone marrow transplantation of three children with thalassemia who received bone marrow, one from an HLA identical but mixed lymphocyte culture-reactive sibling, the other two from an HLA phenotypically identical parent. Evidence of engraftment was detected early (19-21 days) in all three children and only grade II acute GvHD was observed in one patient. Our report indicates that thalassemic patients can be cured by bone marrow transplantation from selected donors other than HLA genotypically identical siblings.
本报告描述了三名地中海贫血患儿成功进行骨髓移植的情况，其中一名患儿接受了来自人类白细胞抗原（HLA）相同但混合淋巴细胞培养反应阳性的同胞的骨髓，另外两名患儿接受了来自HLA表型相同的父母的骨髓。在所有三名患儿中均早期（19 - 21天）检测到植入证据，仅一名患者观察到Ⅱ级急性移植物抗宿主病（GvHD）。我们的报告表明，除了HLA基因型相同的同胞外，地中海贫血患者可通过来自选定供体的骨髓移植治愈。
