Chertkov J L, Drize N J, Gurevitch O A, Samoylova R S
Exp Hematol. 1985 Dec;13(11):1217-22.
Intravenously injected bone marrow cells do not participate in the regeneration of hemopoietic stromal progenitors in irradiated mice, nor in the curetted parts of the recipient's marrow. The hemopoietic stromal progenitors in allogeneic chimeras are of recipient origin. The adherent cell layer (ACL) of long-term cultures of allogeneic chimera bone marrow contains only recipient hemopoietic stromal progenitors. However, in ectopic hemopoietic foci produced by marrow implantation under the renal capsule and repopulated by the recipient hemopoietic cells after irradiation and reconstitution by syngeneic hemopoietic cells, the stromal progenitors were of implant donor origin, as were stromal progenitors of the ACL in long-term cultures of hemopoietic cells from ectopic foci. Our results confirm that the stromal and hemopoietic progenitors differ in origin and that hemopoietic stromal progenitors are not transplantable by the intravenous route in mice.
静脉注射的骨髓细胞不参与受辐照小鼠造血基质祖细胞的再生，也不参与受体骨髓刮除部位的再生。同种异体嵌合体中的造血基质祖细胞来源于受体。同种异体嵌合体骨髓长期培养的贴壁细胞层（ACL）仅含有受体造血基质祖细胞。然而，在肾被膜下植入骨髓产生的异位造血灶中，经辐照并用同基因造血细胞重建后由受体造血细胞重新填充，其基质祖细胞来源于植入供体，异位灶造血细胞长期培养的ACL中的基质祖细胞也是如此。我们的结果证实，基质祖细胞和造血祖细胞来源不同，并且造血基质祖细胞在小鼠中不能通过静脉途径移植。
