Orthopedics Department, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
BMC Nephrol. 2024 Jul 25;25(1):236. doi: 10.1186/s12882-024-03672-1.
Chronic kidney disease (CKD) and osteoarthritis (OA) represent two frequently seen disorders among the general population, and they share several similar risk factors. The present work focused on assessing the relation of CKD with OA.
This cohort study included 26,280 eligible participants aged ≥ 20 years who had valid data on CKD and OA from the National Health and Nutrition Examination Survey (NHANES) 2011-2020. The association between CKD and OA was studied by logistic regression, adjusting for demographics, body mass index (BMI), socioeconomic factors, physical activity, ever smoking, alcohol using, diabetes status and hypertension status.
Among the participants of this study, 26.69% of OA patients had concurrent CKD, whereas this proportion was only 13.83% among non-OA patients.CKD was related to OA[OR:2.269 (95%CI:2.266-2.271), p < 0.01] and the relation was of significance [OR:1.031 (95%CI:1.030-1.033),p < 0.01] following adjustments. In subgroup analyses based on age, the relation between osteoarthritis and chronic kidney disease remained significant, and in the subgroup analyses based on gender the previously mentioned relation between OA and CKD showed opposite directions in men [OR:0.869(95%CI0.867-0.871), p < 0.01] and women [OR:1.178(95%CI1.177-1.180), p < 0.01].
In the present 10-year large-scale national-wide survey, OA is closely related to CKD, and women with OA showed a higher risk of developing CKD compared to men. This study suggests that the relationship between OA and CKD deserves further investigation, and we suggest that patients with OA need to pay extra attention to their own kidney health.
慢性肾脏病（CKD）和骨关节炎（OA）是普通人群中常见的两种疾病，它们有一些共同的危险因素。本研究旨在评估 CKD 与 OA 的关系。
本队列研究纳入了 26280 名年龄≥20 岁的参与者，他们来自 2011 年至 2020 年国家健康和营养检查调查（NHANES），这些参与者有 CKD 和 OA 的有效数据。通过 logistic 回归，调整人口统计学、体重指数（BMI）、社会经济因素、体力活动、吸烟史、饮酒史、糖尿病状态和高血压状态，研究 CKD 与 OA 之间的关系。
在这项研究的参与者中，26.69%的 OA 患者同时患有 CKD，而非 OA 患者的这一比例仅为 13.83%。CKD 与 OA 相关[OR：2.269（95%CI：2.266-2.271），p<0.01]，且经调整后这种关系具有统计学意义[OR：1.031（95%CI：1.030-1.033），p<0.01]。基于年龄的亚组分析中，骨关节炎与慢性肾脏病之间的关系仍然显著，而基于性别进行的亚组分析中，OA 和 CKD 之间的先前提到的关系在男性[OR：0.869（95%CI0.867-0.871），p<0.01]和女性[OR：1.178（95%CI1.177-1.180），p<0.01]中呈现出相反的方向。
在这项为期 10 年的大规模全国性调查中，OA 与 CKD 密切相关，且女性 OA 患者比男性患者发生 CKD 的风险更高。本研究表明，OA 和 CKD 之间的关系值得进一步研究，我们建议 OA 患者需要额外关注自己的肾脏健康。
