Division of Clinical Pharmacology and Therapeutics, Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong, China.
Ann Med. 2022 Dec;54(1):1767-1775. doi: 10.1080/07853890.2022.2089911.
Hypertension and arthritis are two common diseases in the general population, with multiple common risk factors. This study aimed to assess the association between hypertension (HTN) and arthritis.
This cohort study included 48,372 eligible non-pregnant participants aged ≥ 20 years who had valid data on hypertension and arthritis from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. The association between hypertension and arthritis was studied by logistic regression, adjusting for demographics, socioeconomic factors, excess sodium intake, physical activity, ever smoking, diabetes status and body mass index (BMI).
Among the participants, 48.0% (95% CI: 47.2-48.9) had hypertension and 24.5% (95% CI: 23.8-25.3) had self-reported arthritis. Hypertension was associated with arthritis [OR = 2.90, (95% CI: 2.74-3.07), < 0.01], which remained significant [OR = 1.27, (95% CI:1.18-1.37), < 0.01] after adjustments. Stratified by the types of arthritis, the association remained significant in rheumatoid arthritis (RA) [OR = 1.25, (95% CI: 1.11-1.41), < 0.01] and osteoarthritis (OA) [OR = 1.32, (95% CI: 1.16-1.50); < 0.01]. There was no clear association between hypertension and OA in participants aged 60 years old and above [OR = 1.08, (95% CI: 0.92-1.26); = 0.37].
In this large nationally representative survey over 20 years, arthritis, including both RA and OA, was strongly associated with hypertension. Our study demonstrates a need for hypertension screening and blood control among patients with arthritis.Key MessagesArthritis was associated with hypertension.Both rheumatoid arthritis and osteoarthritis are strongly associated with hypertension.There is an urgency for hypertension screening and blood control among patients with arthritis.
高血压和关节炎是普通人群中两种常见的疾病，它们有许多共同的危险因素。本研究旨在评估高血压（HTN）与关节炎之间的关系。
这项队列研究纳入了 48372 名年龄在 20 岁及以上、来自 1999-2018 年国家健康和营养调查（NHANES）的合格非孕妇参与者，他们有高血压和关节炎的有效数据。使用逻辑回归调整人口统计学、社会经济因素、过量钠摄入、身体活动、吸烟史、糖尿病状况和体重指数（BMI）后，研究了高血压与关节炎之间的关系。
在参与者中，48.0%（95%置信区间：47.2-48.9）患有高血压，24.5%（95%置信区间：23.8-25.3）自我报告有关节炎。高血压与关节炎相关（OR=2.90，95%置信区间：2.74-3.07），差异有统计学意义（P<0.01），调整后仍有显著相关性（OR=1.27，95%置信区间：1.18-1.37），差异有统计学意义（P<0.01）。按关节炎类型分层，在类风湿关节炎（RA）（OR=1.25，95%置信区间：1.11-1.41）和骨关节炎（OA）（OR=1.32，95%置信区间：1.16-1.50）中，这种关联仍然显著，差异有统计学意义（P<0.01）。在 60 岁及以上的参与者中，高血压与 OA 之间没有明显关联（OR=1.08，95%置信区间：0.92-1.26），差异无统计学意义（P=0.37）。
在这项超过 20 年的大型全国代表性调查中，关节炎（包括 RA 和 OA）与高血压密切相关。我们的研究表明，关节炎患者需要进行高血压筛查和血压控制。
