Dominguez Elena Nicole, Corrada María M, Kawas Claudia H, Stark Craig E L
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, United States.
Department of Neurology, University of California, Irvine, Irvine, CA, United States.
Front Aging Neurosci. 2024 Jul 11;16:1428695. doi: 10.3389/fnagi.2024.1428695. eCollection 2024.
Successful cognitive aging is often thought to result from resistance to the accumulation of pathology, resilience to the effects of pathological accumulation, or some combination of the two. While evidence for resilience has been found in typical aging populations, the oldest-old provide us with a unique window into the role of pathological accumulation in impacting cognition. Here, we aimed to assess group differences in measures of amyloid and tau across older age groups using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI age: 60-89) and + (age: 90-101). Additionally, using the ADNI dataset, we performed exploratory analyses of regional cingulate AV-45 SUVRs to assess if amyloid load in particular areas was associated with Top Cognitive Performance (TCP). Consistent with the literature, results showed no group differences in amyloid SUVRs both regionally and in the whole cortex. For tau with AV-1451, we also observed no differences in Braak composite SUVRs. Interestingly, these relationships persisted in the oldest-old. This indicates that Top Cognitive Performance throughout aging does not reflect resistance to amyloid and tau burden, but that other mechanisms may be associated with protection against amyloid and tau related neurodegeneration.
成功的认知衰老通常被认为源于对病理积累的抵抗、对病理积累影响的恢复力，或两者的某种组合。虽然在典型的老年人群中已发现恢复力的证据，但最年长的老年人为我们提供了一个独特的窗口，以了解病理积累在影响认知方面的作用。在这里，我们旨在利用来自阿尔茨海默病神经影像倡议（ADNI，年龄60 - 89岁）和ADNI+（年龄90 - 101岁）的数据，评估不同老年组在淀粉样蛋白和tau蛋白测量指标上的组间差异。此外，使用ADNI数据集，我们对扣带回区域的AV - 45标准化摄取值（SUVRs）进行了探索性分析，以评估特定区域的淀粉样蛋白负荷是否与顶级认知表现（TCP）相关。与文献一致，结果显示区域和整个皮质的淀粉样蛋白SUVRs均无组间差异。对于使用AV - 1451检测的tau蛋白，我们在Braak综合SUVRs中也未观察到差异。有趣的是，这些关系在最年长的老年人中依然存在。这表明在整个衰老过程中，顶级认知表现并不反映对淀粉样蛋白和tau蛋白负担的抵抗，而是其他机制可能与预防淀粉样蛋白和tau蛋白相关的神经退行性变有关。
