California National Primate Research Center, University of California, Davis, Davis, CA, United States.
Department of Psychology, University of California, Davis, Davis, CA, United States.
Front Endocrinol (Lausanne). 2024 Jul 11;15:1418089. doi: 10.3389/fendo.2024.1418089. eCollection 2024.
A key goal of the field of endocrinology has been to understand the hormonal mechanisms that drive social behavior and influence reactions to others, such as oxytocin. However, it has sometimes been challenging to understand which aspects and influences of hormonal action are conserved and common among mammalian species, and which effects differ based on features of these species, such as social system. This challenge has been exacerbated by a focus on a relatively small number of traditional model species. In this review, we first demonstrate the benefits of using non-traditional models for the study of hormones, with a focus on oxytocin as a case study in adding species with diverse social systems. We then expand our discussion to explore differing effects of oxytocin (and its response to behavior) within a species, with a particular focus on relationship context and social environment among primate species. Finally, we suggest key areas for future exploration of oxytocin's action centrally and peripherally, and how non-traditional models can be an important resource for understanding the breadth of oxytocin's potential effects.
内分泌学领域的一个主要目标是理解驱动社会行为和影响对他人反应的激素机制，如催产素。然而，有时很难理解激素作用的哪些方面和影响在哺乳动物物种中是保守和共同的，哪些影响因这些物种的特征（如社会系统）而异。这种挑战因专注于相对较少的传统模式物种而加剧。在这篇综述中，我们首先展示了使用非传统模型研究激素的好处，重点关注催产素作为一个案例研究，以增加具有不同社会系统的物种。然后，我们扩展了讨论范围，探讨了同一物种内催产素（及其对行为的反应）的不同影响，特别关注灵长类物种中的关系背景和社会环境。最后，我们提出了未来探索催产素在中枢和外周作用的关键领域，以及非传统模型如何成为理解催产素潜在影响的重要资源。
