Aldajani Ahmad, Alroqi Ahmad, Alramyan Rana, Alhejin Nujud, Alswayyed Mohammed, Alrajban Waleed A, Alromaih Saud, Aloulah Mohammad O, Alrasheed Abdulaziz S, Aldousary Surayie, Alsaleh Saad
Department of Otorhinolaryngology Head & Neck Surgery, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Department of Otolaryngology Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Front Surg. 2024 Jul 10;11:1421140. doi: 10.3389/fsurg.2024.1421140. eCollection 2024.
Chronic Rhinosinusitis (CRS) is a common condition causing a significant worldwide burden, affecting 5%-12% of the general population. CRS is classified into type 2 and non-type 2 disease based on endotype dominance. Type 2 inflammation is distinguished by the presence of IL-4, IL-5, and IL-13 cytokines, along with eosinophil and mast cell activation and recruitment. Evidence of type 2 inflammation is ascertained by tissue eosinophil count >10/high-power field (HPF) or serum eosinophil >250 cells/mcL or total immunoglobulin E (IgE) > 100 IU/ml.
To investigate the prevalence and characteristics of type 2 inflammation in patients who presented with nasal polyps and underwent Endoscopic Sinus Surgery (ESS) in Saudi Arabia.
A retrospective cross-sectional Study.
This study was conducted among patients who presented with nasal polyps and underwent ESS at King Saud University Medical City (KSUMC) from 2015 to 2020. Patients with nasal/sinus diseases other than Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) were excluded. Demographic data, olfaction status, and co-morbidities were collected, and radiological images were evaluated. Type 2-CRS was determined by meeting at least one of three predictor criteria (blood eosinophils ≥250 cells/mcL, tissue eosinophils ≥10/HPF, or total IgE levels ≥100 IU/ml). Blood parameters and histopathologic analysis were obtained for each patient.
Of the 381 patients included in the study, the prevalence of type 2-CRS, based on the EPOS2020 criteria, was 99.7% in our population. Among these patients, 47.5% had hyposmia, 38.8% had anosmia, and 13.6% had normal olfaction. The most prevalent co-morbidity was allergic rhinitis, followed by bronchial asthma.
This study aimed to determine the prevalence of type 2 inflammation among patients Diagnosed with CRSwNP and underwent ESS in Saudi Arabia. The results showed a prevalence of 99.7%, indicating that almost all recorded patients with CRSwNP in our population had type 2 inflammation.
慢性鼻-鼻窦炎（CRS）是一种常见疾病，在全球造成了重大负担，影响着5%-12%的普通人群。根据内型优势，CRS被分为2型和非2型疾病。2型炎症的特征是存在白细胞介素-4（IL-4）、白细胞介素-5（IL-5）和白细胞介素-13（IL-13）细胞因子，以及嗜酸性粒细胞、肥大细胞的激活和募集。2型炎症的证据通过组织嗜酸性粒细胞计数>10/高倍视野（HPF）或血清嗜酸性粒细胞>250个/微升或总免疫球蛋白E（IgE）>100国际单位/毫升来确定。
调查在沙特阿拉伯患有鼻息肉并接受鼻内镜鼻窦手术（ESS）的患者中2型炎症的患病率和特征。
一项回顾性横断面研究。
本研究在2015年至2020年期间于沙特国王大学医学城（KSUMC）患有鼻息肉并接受ESS的患者中进行。排除患有除慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）以外的鼻/鼻窦疾病的患者。收集人口统计学数据、嗅觉状态和合并症，并评估放射学图像。2型CRS通过满足三个预测标准中的至少一个来确定（血液嗜酸性粒细胞≥250个/微升、组织嗜酸性粒细胞≥10/HPF或总IgE水平≥100国际单位/毫升）。为每位患者获取血液参数和组织病理学分析结果。
在纳入研究的381例患者中，根据EPOS2020标准，我们人群中2型CRS的患病率为99.7%。在这些患者中，47.5%有嗅觉减退，38.8%有嗅觉丧失，13.6%嗅觉正常。最常见的合并症是变应性鼻炎，其次是支气管哮喘。
本研究旨在确定在沙特阿拉伯被诊断为CRSwNP并接受ESS的患者中2型炎症的患病率。结果显示患病率为99.7%，表明我们人群中几乎所有记录的CRSwNP患者都有2型炎症。
