Yamaga Masayuki, Kawabe Hiroshi, Tani Hiroko, Yamaki Ayanori
Institute for Bee Products and Health Science, Yamada Bee Company, Inc. Tamata-gun Okayama Japan.
Food Sci Nutr. 2024 Apr 4;12(7):4680-4691. doi: 10.1002/fsn3.4116. eCollection 2024 Jul.
Prenylated cinnamic acid derivatives are the bioactive components of Brazilian green propolis (BGP). The effect of other botanical components on the pharmacokinetic profiles of these derivatives remains relatively unexplored. In the present study, we investigated the influence of several herbal extracts (turmeric, ginkgo leaf, coffee fruit, soybean, and gotu kola) on the plasma concentrations of cinnamic acid derivatives after BGP consumption. When the herbal extracts were co-administered with BGP in the clinical study, the area under the curve (AUC) values of artepillin C and drupanin, the major BGP components in plasma, were significantly increased by 1.7- and 1.5-fold, respectively, compared to those after BGP administration alone. Among the herbal extracts administered to rats, turmeric extract increased the AUC. Furthermore, a bidirectional transport assay suggested that artepillin C and drupanin are substrates of breast cancer resistance protein (BCRP), a drug elimination transporter. These results suggest that curcumin-containing turmeric extract may increase the plasma concentrations of artepillin C and drupanin via BCRP. Our findings enabled us to estimate the food-herb and herb-herb interactions in vivo in foods and herbal medicines containing cinnamic acid derivatives and prenylated compounds.
异戊烯基肉桂酸衍生物是巴西绿蜂胶（BGP）的生物活性成分。其他植物成分对这些衍生物药代动力学特征的影响仍相对未被探索。在本研究中，我们调查了几种草药提取物（姜黄、银杏叶、咖啡果、大豆和积雪草）对摄入BGP后肉桂酸衍生物血浆浓度的影响。在临床研究中，当草药提取物与BGP联合给药时，血浆中主要的BGP成分阿替匹林C和德鲁帕宁的曲线下面积（AUC）值分别比单独给予BGP后显著增加了1.7倍和1.5倍。在给大鼠服用的草药提取物中，姜黄提取物增加了AUC。此外，双向转运试验表明阿替匹林C和德鲁帕宁是乳腺癌耐药蛋白（BCRP，一种药物消除转运体）的底物。这些结果表明，含姜黄素的姜黄提取物可能通过BCRP增加阿替匹林C和德鲁帕宁的血浆浓度。我们的研究结果使我们能够估计含有肉桂酸衍生物和异戊烯基化合物的食品和草药中食物-草药以及草药-草药之间的体内相互作用。
