Huang Jian, Zeng Youjie, Yuan Yuan
Department of Dermatology, Third Xiangya Hospital Central South University Changsha Hunan China.
Department of Anesthesiology, Third Xiangya Hospital Central South University Changsha Hunan China.
Food Sci Nutr. 2024 Mar 31;12(7):4981-4988. doi: 10.1002/fsn3.4147. eCollection 2024 Jul.
Prior studies suggested that vitamin E might be beneficial in alleviating atopic dermatitis, but confirming a causal link was hindered by limitations such as sample sizes and unaccounted confounders. The present study aimed to clarify this through Mendelian randomization (MR) analysis. GWAS summary statistics was obtained from public databases encompassing a study on vitamin E and two studies related to atopic dermatitis. Two sets of instrumental variables (IVs) were selected using lenient ( < 1e-5) and strict ( < 5e-6) thresholds for separate MR analyses. Inverse variance weighted (IVW) was used as the primary MR method, supplemented by six additional MR methods, and followed by a meta-analysis to consolidate the impact of vitamin E on atopic dermatitis from two independent studies. Furthermore, various sensitivity tests were performed to assess the reliability of the MR results. A meta-analysis of IVW analyses deriving from two different atopic dermatitis cohorts under lenient IV selection thresholds demonstrated that vitamin E exhibited a significant lowering risk of atopic dermatitis effect (OR = 0.817, 95% CI: 0.673-0.991, = .041), which was validated under strict IV selection thresholds (OR = 0.822, 95% CI: 0.709-0.954, = .010). In addition, six other MR methods remained parallel to IVW (OR > 1). Multiple sensitivity tests showed that MR analyses were not affected by heterogeneity and horizontal pleiotropy. Overall, this MR study supported vitamin E reducing the risk of atopic dermatitis. Consequently, maintaining an adequate intake of vitamin E could potentially serve as an effective preventive measure against atopic dermatitis.
先前的研究表明，维生素E可能有助于缓解特应性皮炎，但由于样本量和未考虑的混杂因素等限制，确认因果关系受到阻碍。本研究旨在通过孟德尔随机化（MR）分析来阐明这一问题。从公共数据库中获取全基因组关联研究（GWAS）汇总统计数据，这些数据库涵盖了一项关于维生素E的研究以及两项与特应性皮炎相关的研究。使用宽松（<1e-5）和严格（<5e-6）阈值选择两组工具变量（IVs），用于单独的MR分析。采用逆方差加权（IVW）作为主要的MR方法，并辅以另外六种MR方法，随后进行荟萃分析，以整合来自两项独立研究的维生素E对特应性皮炎的影响。此外，还进行了各种敏感性测试，以评估MR结果的可靠性。在宽松的IV选择阈值下，对来自两个不同特应性皮炎队列的IVW分析进行荟萃分析表明，维生素E显示出显著降低特应性皮炎风险的作用（OR = 0.817，95% CI：0.673 - 0.991，P = 0.041），在严格的IV选择阈值下得到验证（OR = 0.822，95% CI：0.709 - 0.954，P = 0.010）。此外，其他六种MR方法与IVW结果一致（OR > 1）。多项敏感性测试表明，MR分析不受异质性和水平多效性的影响。总体而言，这项MR研究支持维生素E可降低特应性皮炎风险。因此，维持足够的维生素E摄入量可能是预防特应性皮炎的有效措施。
