血清维生素 E 水平与慢性炎症性皮肤病：系统评价和荟萃分析。
Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
机构信息
Department of Food Nutrition and Safety, Dalian Medical University, Dalian, China.
Department of Preventive Medicine, Dalian Medical University, Dalian, China.
出版信息
PLoS One. 2021 Dec 14;16(12):e0261259. doi: 10.1371/journal.pone.0261259. eCollection 2021.
BACKGROUND
Vitamin E has long been linked to skin health, including all of its possible functions in cosmetic products, to its roles in membrane integrity and even the aging process. However, reports on the relationship between serum vitamin E levels and the risk of chronic inflammatory skin diseases have been inconsistent. We performed a systematic review and meta-analysis to evaluate the association between serum vitamin E levels and chronic inflammatory skin diseases.
METHODS
We searched the PubMed, Web of Science and Scopus databases, with no time limit up to 30.06.2021. Studies examining serum vitamin E levels in patients with chronic inflammatory skin diseases were selected.
RESULTS
Twenty articles met the inclusion criteria. Compared with controls, a lower vitamin E level was found in patients with vitiligo (SMD: -0.70, 95% CI: -1.21 to -0.19), psoriasis (SMD: -2.73, 95% CI: -3.57 to -1.18), atopic dermatitis (SMD: -1.08, 95% CI: -1.80 to -0.36) and acne (SMD: -0.67, 95% CI: -1.05 to -0.30).
CONCLUSIONS
Our meta-analysis showed that serum vitamin E levels were lower in patients suffering from vitiligo, psoriasis, atopic dermatitis and acne. This study highlights the need to evaluate vitamin E status to improve its level in patients with skin diseases.
背景
维生素 E 一直与皮肤健康有关，包括其在化妆品产品中的所有可能功能、在膜完整性甚至衰老过程中的作用。然而，关于血清维生素 E 水平与慢性炎症性皮肤病风险之间的关系的报告一直不一致。我们进行了系统评价和荟萃分析，以评估血清维生素 E 水平与慢性炎症性皮肤病之间的关系。
方法
我们搜索了 PubMed、Web of Science 和 Scopus 数据库，没有时间限制，截止到 2021 年 6 月 30 日。选择了研究慢性炎症性皮肤病患者血清维生素 E 水平的文章。
结果
20 篇文章符合纳入标准。与对照组相比，白癜风（SMD：-0.70，95%CI：-1.21 至-0.19）、银屑病（SMD：-2.73，95%CI：-3.57 至-1.18）、特应性皮炎（SMD：-1.08，95%CI：-1.80 至-0.36）和痤疮（SMD：-0.67，95%CI：-1.05 至-0.30）患者的维生素 E 水平较低。
结论
我们的荟萃分析表明，患有白癜风、银屑病、特应性皮炎和痤疮的患者血清维生素 E 水平较低。这项研究强调了评估维生素 E 状态以提高皮肤病患者维生素 E 水平的必要性。
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