Zhao Rongrong, Shi Huihui, Wang Yanqiu, Zheng Shuaiyu, Xu Yahui
The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Front Genet. 2024 Jul 11;15:1431769. doi: 10.3389/fgene.2024.1431769. eCollection 2024.
The existence of a shared genetic basis for mental disorders has long been documented, yet research on whether acquired epigenetic modifications exhibit common alterations across diseases is limited. Previous studies have found that abnormal methylation of cg14631053 at the promoter region mediates the onset of alcohol use disorder. However, whether aberrant methylation of the gene promoter is involved in other mental health disorders remains unclear. In this study, leveraging publicly available data, we identified that changes in methylation of cg14631053 from the promoter region are involved in the development of bipolar disorder and schizophrenia. Furthermore, the direction of methylation changes in the promoter region is disease-specific: hypomethylation is associated with the onset of bipolar disorder and schizophrenia, rather than major depressive disorder. Methylation levels of cg14631053 correlate with chronological age, a correlation that can be disrupted in patients with mental health disorders including schizophrenia and bipolar disorder. In conclusion, promoter methylation may serve as a marker for identifying bipolar disorder and schizophrenia, providing insights into a transdiagnostic mechanism for precision medicine in the future.
精神障碍存在共同遗传基础这一点早有文献记载，但关于获得性表观遗传修饰在不同疾病中是否表现出共同改变的研究却很有限。先前的研究发现，启动子区域cg14631053的异常甲基化介导了酒精使用障碍的发病。然而，该基因启动子的异常甲基化是否与其他精神健康障碍有关仍不清楚。在本研究中，我们利用公开可用的数据，确定启动子区域cg14631053的甲基化变化与双相情感障碍和精神分裂症的发生有关。此外，启动子区域甲基化变化的方向具有疾病特异性：低甲基化与双相情感障碍和精神分裂症的发病有关，而非与重度抑郁症有关。cg14631053的甲基化水平与实足年龄相关，这种相关性在包括精神分裂症和双相情感障碍在内的精神健康障碍患者中可能会被破坏。总之，启动子甲基化可能作为识别双相情感障碍和精神分裂症的标志物，为未来精准医学的跨诊断机制提供见解。
