Aljadah Michael, Khan Nabeel, Beyer Andreas M, Chen Yiliang, Blanker Andrew, Widlansky Michael E
Division of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Division of Endocrinology and Molecular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
JACC Adv. 2024 Jul 3;3(8):101070. doi: 10.1016/j.jacadv.2024.101070. eCollection 2024 Aug.
Endothelial dysfunction represents a measurable and early manifestation of vascular disease. Emerging evidence suggests cardiovascular risk remains elevated after COVID-19 infection for at least 12 months, regardless of cardiovascular disease status prior to infection. We review the relationship between the severity of endothelial dysfunction and the severity of acute COVID-19 illness, the degree of impairment following recovery in both those with and without postacute sequalae SARS-CoV-2 infection, and current therapeutic efforts targeting endothelial function in patients following COVID-19 infection. We identify gaps in the literature to highlight specific areas where clinical research efforts hold promise for progress in understanding the connections between endothelial function, COVID-19, and clinical outcomes that will lead to beneficial therapeutics.
内皮功能障碍是血管疾病可测量的早期表现。新出现的证据表明，无论感染前的心血管疾病状况如何，新冠病毒感染后心血管风险至少在12个月内持续升高。我们回顾了内皮功能障碍的严重程度与急性新冠病毒疾病严重程度之间的关系，感染新冠病毒后有和没有急性后遗症的患者恢复后功能受损的程度，以及目前针对新冠病毒感染患者内皮功能的治疗措施。我们找出了文献中的空白，以突出临床研究有望取得进展的特定领域，从而有助于理解内皮功能、新冠病毒和临床结局之间的联系，进而开发出有益的治疗方法。
