揭示O(6)-甲基鸟嘌呤-DNA甲基转移酶在癌症治疗中的作用：对烷化剂、药物基因组学及其他方面的见解
Unveiling the role of O(6)-methylguanine-DNA methyltransferase in cancer therapy: insights into alkylators, pharmacogenomics, and others.
作者信息
Chen Lizhen, Wen Alex
机构信息
Department of Pharmacy, The First Hospital of Putian City, Putian, Fujian, China.
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.
出版信息
Front Oncol. 2024 Jul 11;14:1424797. doi: 10.3389/fonc.2024.1424797. eCollection 2024.
Abstract
Cancer chemotherapy is advancing as we understand how cellular mechanisms and drugs interact, particularly involving the enzyme MGMT, which repairs DNA damage that can cause cancer. This review examines MGMT's role in DNA repair, its impact on chemotherapy, and its complex interaction with radiation therapy. MGMT activity can both protect against mutations and cause drug resistance. Modulating MGMT could improve treatment efficacy and tailoring therapy to MGMT status may enhance patient outcomes. Understanding MGMT is crucial for developing precise cancer treatments and advancing patient care.
摘要
随着我们对细胞机制与药物相互作用的理解不断深入，癌症化疗也在不断发展，尤其涉及到可修复能引发癌症的DNA损伤的酶——甲基鸟嘌呤甲基转移酶（MGMT）。本综述探讨了MGMT在DNA修复中的作用、其对化疗的影响以及它与放射治疗的复杂相互作用。MGMT活性既能预防突变，也会导致耐药性。调节MGMT可以提高治疗效果，根据MGMT状态定制治疗方案可能会改善患者预后。了解MGMT对于开发精准癌症治疗方法和推进患者护理至关重要。
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