解读抗肿瘤药物疗效和毒性中的基因突变：肿瘤药师的视角
Deciphering gene mutations in the efficacy and toxicity of antineoplastic drugs: an oncology pharmacist's perspective.
作者信息
Jiang Yucai, Wen Guolin Alexander
机构信息
Department of Pharmacy, Affiliated Hospital of Putian University, Putian, Fujian, China.
Department of Pharmacy, Dana-Farber Cancer Institute, Boston, MA, United States.
出版信息
Front Pharmacol. 2025 Mar 20;16:1574010. doi: 10.3389/fphar.2025.1574010. eCollection 2025.
BACKGROUND/OBJECTIVES: This article reviews some key emerging pharmacogenomic topics in oncology pharmacy practice.
METHODS
Publications selected to review were mainly sourced from the new drug approvals by the Food and Drug Administration and the new regimens listed in the National Comprehensive Cancer Network.
RESULTS
Key pharmacogenomic topics were presented, including genetic alterations influencing drug metabolism, drug efficacy, and changes in therapeutic targeting; Relevant clinical updates and advancements were summarized to provide an in-depth understanding.
CONCLUSION
The abundance of pharmacogenomic measures builds a solid foundation and heralds a paradigm shift toward individualized patient care.
背景/目的：本文综述了肿瘤药学实践中一些关键的新兴药物基因组学主题。
方法
所选用于综述的出版物主要来源于美国食品药品监督管理局的新药批准以及美国国立综合癌症网络列出的新治疗方案。
结果
介绍了关键的药物基因组学主题，包括影响药物代谢、药物疗效的基因改变以及治疗靶点的变化；总结了相关的临床更新和进展以提供深入理解。
结论
大量的药物基因组学措施奠定了坚实基础，并预示着向个体化患者护理的模式转变。
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