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补充马胎盘提取物对两只狗角膜伤口的影响:病例报告。

Supplementation of equine placenta extract on corneal wound in two dogs: Case report.

机构信息

Nakagaki Animal Hospital, Tajimi City, Gifu, Japan.

Authors contributed equally to this work.

出版信息

Open Vet J. 2024 Jun;14(6):1503-1508. doi: 10.5455/OVJ.2024.v14.i6.20. Epub 2024 Jun 30.

DOI:10.5455/OVJ.2024.v14.i6.20
PMID:39055764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11268901/
Abstract

BACKGROUND

Canine corneal disease is a common condition encountered in daily practice. If the depth of corneal damage is limited to the epithelial layer, healing is often straightforward; however, if it extends into the epithelial basement membrane or corneal parenchyma, surgical treatment is the treatment of choice. Moreover, in cases where there is an underlying disease or where the owner refuses surgical treatment, treatment options are often limited to eye drop treatment, which may be inadequate.

CASE DESCRIPTION

Dogs aged 10 and 14 years were admitted to the hospital with eye injuries. Based on the examination findings, the owner believed that surgical treatment would be effective; however, this could not be performed owing to the underlying condition of the cases. Hyaluronic acid and antibiotic eye drops were administered, but there was no improvement in the eye damage. The eye-drop treatment was prolonged without any improvement, and in the meantime the patients' weakness became apparent. In parallel with the eye-drop treatment, the patients were given a supplement containing equine placental extract to help restore their physical fitness. Consequently, in addition to the recovery of physical fitness, a film gradually formed over the eye damage area and injuries improved eventually.

CONCLUSION

Based on these cases, supplementation with equine placenta extract may be an effective treatment option for ocular conditions that are difficult to treat surgically.

摘要

背景

犬角膜疾病是日常临床中常见的病症。如果角膜损伤的深度仅限于上皮层,通常可以自行愈合;但如果损伤延伸至上皮基底膜或角膜实质层,则需要手术治疗。此外,对于存在潜在疾病或主人拒绝手术治疗的病例,治疗选择通常仅限于眼药水治疗,但这可能并不足够。

病例描述

两只年龄分别为 10 岁和 14 岁的犬因眼部受伤而入院。根据检查结果,主人认为手术治疗可能有效;但由于病例的潜在疾病,无法进行手术。因此,给犬使用了透明质酸和抗生素眼药水,但眼部损伤没有改善。尽管延长了眼药水治疗时间,但仍未见改善,同时犬的虚弱症状变得明显。在继续进行眼药水治疗的同时,给犬使用了含有马胎盘提取物的补充剂,以帮助恢复其体能。结果,除了体能的恢复,眼损伤区域逐渐形成了一层膜,损伤最终得到了改善。

结论

基于这些病例,使用马胎盘提取物补充剂可能是一种治疗难以手术治疗的眼部疾病的有效方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dca/11268901/cf5ab2bffaea/OpenVetJ-14-1503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dca/11268901/f16d00338e3c/OpenVetJ-14-1503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dca/11268901/7f02534a0dc4/OpenVetJ-14-1503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dca/11268901/cf5ab2bffaea/OpenVetJ-14-1503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dca/11268901/f16d00338e3c/OpenVetJ-14-1503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dca/11268901/7f02534a0dc4/OpenVetJ-14-1503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dca/11268901/cf5ab2bffaea/OpenVetJ-14-1503-g003.jpg

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本文引用的文献

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Open Vet J. 2023 May;13(5):668-676. doi: 10.5455/OVJ.2023.v13.i5.21. Epub 2023 May 27.
2
Successful treatment of ascites accumulation and diarrhea associated with protein-losing enteropathy with oral equine placenta extract supplementation in a dog: A case report.成功治疗一例犬蛋白丢失性肠病伴腹水积聚和腹泻:口服马胎盘提取物补充治疗的病例报告。
Open Vet J. 2022 Sep-Oct;12(5):774-781. doi: 10.5455/OVJ.2022.v12.i5.24. Epub 2022 Oct 15.
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Assessment and Management of Declining Physical Function in Aging Dogs.
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Top Companion Anim Med. 2022 Nov-Dec;51:100732. doi: 10.1016/j.tcam.2022.100732. Epub 2022 Oct 21.
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A Novel Heptapeptide, GPPGPAG Transfers to the Brain, and Ameliorates Memory Dysfunction and Dendritic Atrophy in Alzheimer's Disease Model Mice.一种新型七肽GPPGPAG可进入大脑,并改善阿尔茨海默病模型小鼠的记忆功能障碍和树突萎缩。
Front Pharmacol. 2021 May 14;12:680652. doi: 10.3389/fphar.2021.680652. eCollection 2021.
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