Nagata Maho, Nakamura Takahiro, Hata Yuiko, Yamaguchi Shumpei, Kaku Taiichi, Kinoshita Shigeru
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Research Center for Inflammation and Regenerative Medicine, Doshisha University, Kyoto, Japan.
Sci Rep. 2015 Oct 1;5:14776. doi: 10.1038/srep14776.
Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In the present study, it was found that placental extract-derived dipeptide (JBP485) significantly increased the proliferation and migration of corneal epithelial cells (CECs). Moreover, JBP485 accelerated corneal epithelial wound healing in vivo without inflammation and neovascularization and was found to be effective for the treatment of corneal damage. These data indicate that JBP485 efficiently activates the viability of CECs and has potential as a novel treatment for various kinds of corneal epithelial disease.
适当的伤口愈合对于维持角膜完整性和透明度至关重要。角膜上皮损伤是最常见的眼部疾病之一。由于临床治疗选择有限，需要进一步的新型治疗方法来改善这类疾病的临床疗效。在本研究中，发现胎盘提取物衍生的二肽（JBP485）显著增加了角膜上皮细胞（CEC）的增殖和迁移。此外，JBP485在体内加速了角膜上皮伤口愈合，且无炎症和新生血管形成，被发现对角膜损伤治疗有效。这些数据表明，JBP485能有效激活CEC的活力，具有作为各种角膜上皮疾病新型治疗方法的潜力。
