绘制胃肠道微生物群与骨代谢的知识图谱和研究前沿：一项文本挖掘研究。

INTRODUCTION: Extensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on the processes of bone formation. Nonetheless, a notable gap exists in the literature concerning a bibliometric analysis of research trends at the nexus of gastrointestinal microbiota and bone metabolism. METHODS: To address this scholarly void, the present study employs a suite of bibliometric tools including online platforms, CiteSpace and VOSviewer to scrutinize the pertinent literature in the realm of gastrointestinal microbiota and bone metabolism. RESULTS AND DISCUSSION: Examination of the temporal distribution of publications spanning from 2000 to 2023 reveals a discernible upward trajectory in research output, characterized by an average annual growth rate of 19.2%. Notably, China and the United States emerge as primary contributors. Predominant among contributing institutions are Emory University, Harvard University, and the University of California. Pacifici R from Emory University contributed the most research with 15 publications. In the realm of academic journals, emerges as the foremost publisher, followed closely by and . And attains the highest average citations of 32.48. Analysis of highly cited papers underscores a burgeoning interest in the therapeutic potential of probiotics or probiotic blends in modulating bone metabolism by augmenting host immune responses. Notably, significant research attention has coalesced around the therapeutic interventions of probiotics, particularly , in osteoporosis, as well as the role of gastrointestinal microbiota in the etiology and progression of osteoarthritis. Keyword analysis reveals prevalent terms including gut microbiota, osteoporosis, bone density, probiotics, inflammation, SCFAs, metabolism, osteoarthritis, calcium absorption, obesity, double-blind, prebiotics, mechanisms, postmenopausal women, supplementation, risk factors, oxidative stress, and immune system. Future research endeavors warrant a nuanced exploration of topics such as inflammation, obesity, SCFAs, postmenopausal osteoporosis, skeletal muscle, oxidative stress, double-blind trials, and pathogenic mechanisms. In summary, this study presents a comprehensive bibliometric analysis of global research on the interplay between gastrointestinal microbiota and bone metabolism, offering valuable insights for scholars, particularly nascent researchers, embarking on analogous investigations within this domain.

简介：大量研究致力于阐明胃肠道微生物群及其代谢物影响骨形成过程的复杂途径。然而，关于胃肠道微生物群和骨代谢交汇点研究趋势的文献计量分析在文献中存在显著空白。

方法：为了解决这一学术空白，本研究采用了一系列文献计量工具，包括在线平台、CiteSpace 和 VOSviewer，来仔细研究胃肠道微生物群和骨代谢领域的相关文献。

结果与讨论：对 2000 年至 2023 年发表的文献的时间分布进行检查，发现研究产出呈明显上升趋势，平均年增长率为 19.2%。值得注意的是，中国和美国是主要贡献者。主要贡献机构包括埃默里大学、哈佛大学和加利福尼亚大学。埃默里大学的 Pacifici R 发表的研究最多，有 15 篇。在学术期刊领域，是主要出版商，其次是和。获得的平均引用率最高，为 32.48。对高引用论文的分析强调了益生菌或益生菌混合物通过增强宿主免疫反应来调节骨代谢的治疗潜力日益受到关注。值得注意的是，益生菌的治疗干预措施，特别是，在骨质疏松症以及胃肠道微生物群在骨关节炎的病因和进展中的作用方面，引起了显著的研究关注。关键词分析揭示了常见术语，包括肠道微生物群、骨质疏松症、骨密度、益生菌、炎症、SCFAs、代谢、骨关节炎、钙吸收、肥胖、双盲、益生元、机制、绝经后妇女、补充、风险因素、氧化应激和免疫系统。未来的研究工作需要对炎症、肥胖、SCFAs、绝经后骨质疏松症、骨骼肌、氧化应激、双盲试验和发病机制等主题进行细致的探索。总之，本研究对全球胃肠道微生物群和骨代谢相互作用的研究进行了全面的文献计量分析，为学者们，特别是在该领域开展类似研究的新生研究人员提供了有价值的见解。