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肠道微生物群与帕金森病关系的研究趋势和热点:文献计量分析。

Trends and hotspots on the relationship between gut microbiota and Parkinson's Disease: a bibliometric analysis.

机构信息

Changchun University of Chinese Medicine, Changchun, China.

The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.

出版信息

Front Cell Infect Microbiol. 2024 Sep 30;14:1421270. doi: 10.3389/fcimb.2024.1421270. eCollection 2024.


DOI:10.3389/fcimb.2024.1421270
PMID:39403202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11472709/
Abstract

Parkinson's disease (PD) is a neurodegenerative disorder that significantly impacts patients' quality of life. Recent evidence has highlighted a complex relationship between the gut microbiota (GM) and PD. Understanding this relationship is crucial for potentially targeting GM in PD treatment and expanding therapeutic options. This study aimed to comprehensively analyze the global landscape, trends, and research focus on GM and PD using bibliometric analysis. Utilizing publications from the Web of Science Core Collection (WsSCC), bibliometric tools such as the R package 'Bibliometrix,' VOS viewer, and CiteSpace software were employed to assess parameters like yearly publications, countries/regions, institutions, and authors. Research trends and hotspots were identified through keyword analysis. The results revealed 1,161 articles published between 2013-2023, with China leading in publications (n=352, 30.31% of total), while the United States had a higher influence (H-index=58). The University of California System was the top institution in terms of publications (n=35), with the National Natural Science Foundation of China funding the most projects (n=172). Keshavarzian A and Sampson TR were the authors with the highest publication and co-citation counts, respectively. The had the most articles published (n=48). Keyword analysis identified parkinson's disease, gut microbiota, short-chain fatty acids, inflammation, and probiotics as main research topics. Biomarkers, ketogenic diet, and NF-κB were recent research hotspots and trends (2021-2023). The current study conducts an objective and comprehensive analysis of these publications, identifying trends and hotspots in the field of research. The findings offer valuable insights to scholars globally and in-vestigate potential therapeutic strategies for Parkinson's Disease.

摘要

帕金森病(PD)是一种神经退行性疾病,严重影响患者的生活质量。最近的证据强调了肠道微生物群(GM)与 PD 之间的复杂关系。了解这种关系对于在 PD 治疗中靶向 GM 并扩大治疗选择至关重要。本研究旨在通过文献计量分析全面分析 GM 与 PD 相关研究的全球格局、趋势和研究重点。利用 Web of Science 核心合集(WsSCC)中的出版物,使用 R 包“Bibliometrix”、VOS viewer 和 CiteSpace 软件等文献计量工具评估年度出版物、国家/地区、机构和作者等参数。通过关键词分析确定研究趋势和热点。结果显示,2013 年至 2023 年间共发表了 1161 篇文章,中国在发表的文章数量上处于领先地位(n=352,占总数的 30.31%),而美国的影响力较高(H 指数=58)。在发表文章方面,加州大学系统排名第一(n=35),中国国家自然科学基金资助的项目最多(n=172)。Keshavarzian A 和 Sampson TR 分别是发表文章和共同引用文章数量最多的作者。《Parkinsonism & related disorders》发表的文章最多(n=48)。关键词分析确定了帕金森病、肠道微生物群、短链脂肪酸、炎症和益生菌是主要的研究主题。生物标志物、生酮饮食和 NF-κB 是最近的研究热点和趋势(2021-2023 年)。本研究对这些出版物进行了客观和全面的分析,确定了该领域研究的趋势和热点。研究结果为全球学者提供了有价值的见解,并为帕金森病的潜在治疗策略提供了参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/c00e5c957883/fcimb-14-1421270-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/c8ab5a7a40de/fcimb-14-1421270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/a04b67fdb83c/fcimb-14-1421270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/2c0678d25012/fcimb-14-1421270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/0f9e978331fa/fcimb-14-1421270-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/1cc729e6df8a/fcimb-14-1421270-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/e9663d8d4b38/fcimb-14-1421270-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/c00e5c957883/fcimb-14-1421270-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/c8ab5a7a40de/fcimb-14-1421270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/a04b67fdb83c/fcimb-14-1421270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/2c0678d25012/fcimb-14-1421270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/0f9e978331fa/fcimb-14-1421270-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/1cc729e6df8a/fcimb-14-1421270-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/e9663d8d4b38/fcimb-14-1421270-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c0/11472709/c00e5c957883/fcimb-14-1421270-g007.jpg

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引用本文的文献

[1]
Influential articles in autism and gut microbiota: bibliometric profile and research trends.

Front Microbiol. 2025-1-9

[2]
Bacterial products initiation of alpha-synuclein pathology: an in vitro study.

Sci Rep. 2024-12-5

本文引用的文献

[1]
Co-administration of probiotics and vitamin D reduced disease severity and complications in patients with Parkinson's disease: a randomized controlled clinical trial.

Psychopharmacology (Berl). 2024-9

[2]
Efficacy of probiotic supplements on Parkinson's disease: A systematic review and meta-analysis.

Complement Ther Med. 2024-6

[3]
Supplementation of probiotic Bifidobacterium breve Bif11 reverses neurobehavioural deficits, inflammatory changes and oxidative stress in Parkinson's disease model.

Neurochem Int. 2024-3

[4]
Circulating Extracellular Vesicles as a Potential Mediator of Synuclein Pathology in the Gut.

Mov Disord. 2024-1

[5]
Worldwide research trends on tumor burden and immunotherapy: a bibliometric analysis.

Int J Surg. 2024-3-1

[6]
Ketogenic diet protects MPTP-induced mouse model of Parkinson's disease via altering gut microbiota and metabolites.

MedComm (2020). 2023-5-16

[7]
Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives.

Nat Commun. 2023-5-2

[8]
An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson's disease participants.

Nat Commun. 2023-2-18

[9]
α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.

J Neuroinflammation. 2023-2-14

[10]
Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis.

Ageing Res Rev. 2023-2

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