School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine (TCM), Chengdu, China.
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Immunol. 2024 May 13;15:1412640. doi: 10.3389/fimmu.2024.1412640. eCollection 2024.
Gut microbiota is an important factor affecting host health. With the further study of the mechanism of gut microbiota, significant progress has been made in the study of the link between gut microbiota and epigenetics. This study visualizes the body of knowledge and research priorities between the gut microbiota and epigenetics through bibliometrics.
Publications related to gut microbiota and epigenetics were searched in the Web of Science Core Collection (WoSCC) database. Vosviewer 1.6.17 and CiteSpace 6.1.R2 were used for bibliometric analysis.
WoSCC includes 460 articles from 71 countries. The number of publications on gut microbiota and epigenetics has increased each year since 2011. The USA, PEOPLES R CHINA, and ITALY are at the center of this field of research. The University of California System, Harvard University, and the University of London are the main research institutions. Li, X, Yu, Q, Zhang, S X are the top authors in this research field. We found that current research hotspots and frontiers include short-chain fatty acids (SCFA) play an important role in gut microbiota and epigenetic mechanisms, gut microbiota and epigenetics play an important role in host obesity, diet, and metabolism. Gut microbiota and epigenetics are closely related to colorectal cancer, breast cancer, and inflammatory bowel disease. At the same time, we found that gut microbiota regulates epigenetics through the gut-brain axis and has an impact on psychiatric diseases. Therefore, probiotics can regulate gut microbiota, improve lifestyle, and reduce the occurrence and development of diseases.
This is the first comprehensive and in-depth bibliometric study of trends and developments in the field of gut microbiota and epigenetics research. This study helps to guide the direction of research scholars in their current field of study.
肠道微生物群是影响宿主健康的重要因素。随着对肠道微生物群机制的进一步研究，在肠道微生物群与表观遗传学之间的联系研究方面取得了重大进展。本研究通过文献计量学方法可视化了肠道微生物群与表观遗传学之间的知识体系和研究重点。
在 Web of Science 核心合集（WoSCC）数据库中检索与肠道微生物群和表观遗传学相关的出版物。使用 Vosviewer 1.6.17 和 CiteSpace 6.1.R2 进行文献计量分析。
WoSCC 包括来自 71 个国家的 460 篇文章。自 2011 年以来，每年关于肠道微生物群和表观遗传学的出版物数量都在增加。美国、中华人民共和国和意大利处于该研究领域的中心位置。加利福尼亚大学系统、哈佛大学和伦敦大学是主要的研究机构。李、于、张是该研究领域的顶级作者。我们发现，目前的研究热点和前沿包括短链脂肪酸（SCFA）在肠道微生物群和表观遗传机制中发挥着重要作用、肠道微生物群和表观遗传学在宿主肥胖、饮食和代谢中起着重要作用、肠道微生物群和表观遗传学与结直肠癌、乳腺癌和炎症性肠病密切相关。同时，我们发现肠道微生物群通过肠-脑轴调节表观遗传学，对精神疾病有影响。因此，益生菌可以调节肠道微生物群，改善生活方式，减少疾病的发生和发展。
这是对肠道微生物群和表观遗传学研究领域趋势和发展的首次全面深入的文献计量学研究。本研究有助于指导研究学者在当前研究领域的研究方向。
