Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences & Research University (DPSRU), New Delhi, 110017, India.
Department of Pharmaceutics, College of Pharmacy, Jazan University, P. Box No. 114, Jazan, Saudi Arabia.
Nanomedicine (Lond). 2024;19(18-20):1659-1673. doi: 10.1080/17435889.2024.2370759. Epub 2024 Jul 26.
The aim of this study was to optimize, develop, characterize and evaluate a topical nanobigel (BG) formulation containing Berberine (BRB) that exhibits anti-melanogenic properties. The Berberine-loaded bigel (BRB@BG) formulation was prepared by homogenously mixing the optimized hydrogel and oleogel. BRB@BG was characterized and cytotoxicity study was conducted to evaluate its effects on murine skin melanoma B16F10 cell lines. The optimized BRB@BG exhibited uniform texture with nanometric size, desirable spreadability and extrudability, suitable for topical applications. Cytotoxicity studies revealed that BRB@BG had a lower IC value (4.84 μg/ml) on B16F10 cell lines compared with drug alone. In conclusion, the developed BRB@BG formulation showed good potential as safe and effective topical treatment for hyperpigmentation.
本研究旨在优化、开发、表征和评价一种含有具有抗黑色素生成特性的小檗碱（BRB）的局部纳米比格凝胶（BG）制剂。通过均匀混合优化的水凝胶和油凝胶制备载小檗碱的比格凝胶（BRB@BG）制剂。对 BRB@BG 进行了表征，并进行了细胞毒性研究，以评估其对小鼠皮肤黑色素瘤 B16F10 细胞系的影响。优化的 BRB@BG 表现出均匀的纳米尺寸质地、理想的铺展性和可挤出性，适合局部应用。细胞毒性研究表明，BRB@BG 在 B16F10 细胞系上的 IC 值（4.84μg/ml）低于单独用药。总之，开发的 BRB@BG 制剂具有作为安全有效的局部治疗色素沉着过度的潜力。
