嗅觉功能作为男性和女性认知障碍的潜在预测指标

Olfactory Function as a Potential Predictor of Cognitive Impairment in Men and Women.

作者信息

Masala Carla, Loy Francesco, Pinna Ilenia, Manis Nicoletta Aurora, Ercoli Tommaso, Solla Paolo

机构信息

Department of Biomedical Sciences, University of Cagliari, SP 8 Cittadella Universitaria, 09042 Monserrato, Italy.

Neurological Unit, AOU Sassari, University of Sassari, Viale S. Pietro 10, 07100 Sassari, Italy.

出版信息

Biology (Basel). 2024 Jul 5;13(7):503. doi: 10.3390/biology13070503.

DOI:10.3390/biology13070503

PMID:39056696

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274230/

Abstract

BACKGROUND

Different previous studies indicated olfactory function as a predictor of several types of cognitive impairment, in particular related to neurodegenerative disease. However, scanty data are available on the role of odor threshold (OT), odor discrimination (OD), and odor identification (OI) as a predictor of cognitive impairment. The aim of this study was to evaluate potential correlations between each factor of the olfactory function versus each specific cognitive domain of the Montreal Cognitive Assessment (MoCA) test on healthy subjects in relation to gender and age.

METHODS

Sniffin' Sticks and MoCA tests were used to determine olfactory function and cognitive abilities, respectively.

RESULTS

In men, significant correlations were found in OT versus language index score and OI versus language and executive index score, while in women, OD and OI were correlated to visuospatial index score.

CONCLUSIONS

Our data suggested that olfactory function (OT, OD, and OI) may be considered a predictor for cognitive impairment in relation to gender and age.

摘要

背景

先前的不同研究表明嗅觉功能是几种认知障碍类型的预测指标，尤其是与神经退行性疾病相关的认知障碍。然而，关于气味阈值（OT）、气味辨别（OD）和气味识别（OI）作为认知障碍预测指标的作用，现有数据较少。本研究的目的是评估嗅觉功能的各个因素与蒙特利尔认知评估（MoCA）测试的每个特定认知领域之间在健康受试者中与性别和年龄相关的潜在相关性。