Department of Biomedical Sciences, Physiology Section, University of Cagliari, Monserrato, Cagliari, Italy.
Allergy and Clinical Immunology Unit, Department of Medical Sciences and Public Health, University Hospital "Duilio Casula," Monserrato, Cagliari, Italy.
J Allergy Clin Immunol Pract. 2021 Mar;9(3):1359-1364. doi: 10.1016/j.jaip.2020.09.061. Epub 2020 Oct 13.
Mastocytosis is a clinically heterogeneous disorder associated with abnormal mast cell accumulation in different organs. No data are available as regards the assessment of olfactory function and its association with mastocytosis.
The aim of the study was first to investigate odor threshold, discrimination, and identification in patients with mastocytosis compared with age-matched healthy controls (HC), and furthermore, to correlate olfactory function with the other clinical symptoms of mastocytosis.
Eighty-one participants were enrolled: 41 patients with mastocytosis (23 males and 18 females; mean age, 47.95 years; standard deviation [SD], 14.7 years) were compared with 40 HC (23 males and 17 females; mean age, 47.88 years; SD, 14.6 years). Olfactory function among participants was evaluated using the "Sniffin' Sticks" test for odor detection threshold (OT), odor discrimination (OD), and odor identification (OI).
Patients with systemic mastocytosis showed a significant decrease in the total olfactory function (Threshold-Discrimination-Identification [TDI] score), OT, OD, and OI compared with HC. A significant negative correlation was observed only between TDI score and serum tryptase concentration (μg/L). No correlation was observed between disease duration versus OT, OD, OI, and TDI score.
Our results suggest that the olfactory function is impaired in patients compared with HC; a significant negative correlation was found between TDI score and the level of serum tryptase. Olfactory dysfunction in mastocytosis may be considered among the clinical manifestations contributing to the burden of this disease.
肥大细胞增多症是一种临床异质性疾病，与不同器官中异常肥大细胞的积累有关。目前尚无关于嗅觉功能评估及其与肥大细胞增多症之间关系的相关数据。
本研究旨在首先比较肥大细胞增多症患者与年龄匹配的健康对照者（HC）的嗅觉阈值、辨别力和识别能力，并且进一步探讨嗅觉功能与肥大细胞增多症的其他临床症状之间的相关性。
共纳入 81 名参与者：41 名肥大细胞增多症患者（23 名男性和 18 名女性；平均年龄为 47.95 岁；标准差 [SD]，14.7 岁）与 40 名 HC（23 名男性和 17 名女性；平均年龄为 47.88 岁；SD，14.6 岁）进行比较。使用“Sniffin' Sticks”测试评估参与者的嗅觉功能，包括嗅觉检测阈值（OT）、嗅觉辨别（OD）和嗅觉识别（OI）。
与 HC 相比，系统性肥大细胞增多症患者的总嗅觉功能（阈值-辨别-识别 [TDI] 评分）、OT、OD 和 OI 均显著降低。仅在 TDI 评分与血清胰蛋白酶浓度（μg/L）之间观察到显著的负相关。未观察到疾病持续时间与 OT、OD、OI 和 TDI 评分之间的相关性。
我们的研究结果表明，与 HC 相比，患者的嗅觉功能受损；TDI 评分与血清胰蛋白酶水平之间存在显著的负相关。肥大细胞增多症中的嗅觉功能障碍可能被视为该疾病负担的临床表现之一。
