Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Mar Drugs. 2024 Jun 21;22(7):288. doi: 10.3390/md22070288.
The prevention and treatment of liver disease, a class of disease that seriously threatens human health, has always been a hot topic of medical research. In recent years, with the in-depth exploration of marine resources, marine natural products have shown great potential and value in the field of liver disease treatment. Compounds extracted and isolated from marine natural products have a variety of biological activities such as significant antiviral properties, showing potential in the management of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), protection of the liver from fibrosis, protection from liver injury and inhibition of the growth of hepatocellular carcinoma (HCC). This paper summarizes the progress of research on marine natural products for the treatment of liver diseases in the past decade, including the structural types of active substances from different natural products and the mechanisms underlying the modulation of different liver diseases and reviews their future prospects.
肝脏疾病的防治一直是医学研究的热点,肝脏疾病是一类严重威胁人类健康的疾病。近年来,随着海洋资源的深入探索,海洋天然产物在肝脏疾病治疗领域显示出巨大的潜力和价值。从海洋天然产物中提取和分离的化合物具有多种生物活性,如显著的抗病毒特性,在酒精性肝病 (ALD) 和非酒精性脂肪性肝病 (NAFLD) 的管理、肝纤维化的保护、肝损伤的保护和抑制肝癌 (HCC) 的生长方面具有潜在的应用价值。本文总结了过去十年中海洋天然产物在肝脏疾病治疗方面的研究进展,包括不同天然产物中活性物质的结构类型以及调节不同肝脏疾病的机制,并对其未来前景进行了综述。