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海洋微生物天然产物的抗病毒潜力。

Antiviral potential of natural products from marine microbes.

机构信息

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, 315832, China.

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, 315832, China.

出版信息

Eur J Med Chem. 2020 Dec 1;207:112790. doi: 10.1016/j.ejmech.2020.112790. Epub 2020 Aug 31.

Abstract

Humans have been suffered from viral infections over the centuries, such as influenza, HSV, and HIV, which have killed millions of people worldwide. However, the availability of effective treatments for infectious diseases remains limited until now, as most of the viral pathogens resisted to many medical treatments. Marine microbes are currently one of the most copious sources of pharmacologically active natural products, which have constantly provided promising antivirus agents. To date, a large number of marine microbial secondary metabolites with antiviral activities have been widely reported. In this review, we have summarized the potential antivirus compounds from marine microorganisms over the last decade. In addition, the structures, bioactivities, and origins of these compounds were discussed as well.

摘要

人类几个世纪以来一直受到病毒感染的困扰,如流感、HSV 和 HIV,这些病毒在全球范围内已经导致数百万人死亡。然而,直到现在,对于传染病的有效治疗方法仍然有限,因为大多数病毒病原体对许多医学治疗方法都有抵抗力。海洋微生物是目前最丰富的具有药理活性天然产物的来源之一,它们不断提供有前途的抗病毒药物。迄今为止,已经广泛报道了大量具有抗病毒活性的海洋微生物次生代谢产物。在这篇综述中,我们总结了过去十年中来自海洋微生物的潜在抗病毒化合物。此外,还讨论了这些化合物的结构、生物活性和来源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048e/7457942/5c2174fc38f6/fx1_lrg.jpg

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