Popescu Marius Nicolae, Căpeț Claudiu, Beiu Cristina, Berteanu Mihai
Department of Physical and Rehabilitation Medicine-Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Clinic of Physical and Rehabilitation Medicine-Elias Emergency University Hospital, 011461 Bucharest, Romania.
Toxins (Basel). 2025 Feb 26;17(3):107. doi: 10.3390/toxins17030107.
Post-stroke spasticity significantly impairs upper limb function and quality of life. Ultrasound-guided botulinum toxin-A (BoNT-A) injections have become a cornerstone of management, enhancing precision and safety. This paper offers a comprehensive guide for clinicians on ultrasound-guided BoNT-A injections for distal upper limb muscles. Each muscle is detailed in terms of its role in spasticity management, ultrasound identification with key anatomical landmarks, clinical relevance, and injection strategies. Motor points, traditionally identified through anatomical studies or electromyography (EMG), are precisely localized using a musculoskeletal ultrasound by targeting the point of maximum muscle thickness, often corresponding to the motor point. The authors present their clinical method, developed at Elias University Hospital (EUH), to refine BoNT-A injection practices. This approach enhances efficacy, reduces dosage requirements, and improves patient outcomes. The paper also explores unique ultrasound characteristics of spastic muscles, such as their relationship with peripheral nerves, adjacent vascular and muscular structures, and intra- and intermuscular fascia, to guide clinicians in targeting functional muscle tissue. This guide is illustrated with representative ultrasound images and clinical diagrams and provides practical insights into anatomical relationships and injection techniques. Part I focuses on distal upper limb muscles, with Part II addressing proximal upper limb muscles.
中风后痉挛严重损害上肢功能和生活质量。超声引导下肉毒毒素A(BoNT-A)注射已成为治疗的基石,提高了精准度和安全性。本文为临床医生提供了一份关于超声引导下对上肢远端肌肉进行BoNT-A注射的全面指南。详细介绍了每块肌肉在痉挛管理中的作用、通过关键解剖标志进行超声识别、临床意义及注射策略。传统上通过解剖学研究或肌电图(EMG)确定的运动点,利用肌肉骨骼超声通过靶向最大肌肉厚度点(通常对应运动点)来精确定位。作者介绍了他们在伊莱亚斯大学医院(EUH)开发的临床方法,以优化BoNT-A注射操作。这种方法提高了疗效,减少了剂量需求,并改善了患者预后。本文还探讨了痉挛肌肉独特的超声特征,如它们与周围神经、相邻血管和肌肉结构以及肌内和肌间筋膜的关系,以指导临床医生靶向功能性肌肉组织。本指南配有代表性的超声图像和临床示意图,并提供了有关解剖关系和注射技术的实用见解。第一部分聚焦于上肢远端肌肉,第二部分则讨论上肢近端肌肉。