• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Hepatic lipopolysaccharide binding protein partially uncouples inflammation from fibrosis in MAFLD.

作者信息

Wang Dan, Baghoomian Ania, Zhang Zhengyi, Cui Ya, Whang Emily C, Li Xiang, Fraga Josue, Spellman Rachel Ariana, Dong Tien S, Li Wei, Gupta Arpana, Benhammou Jihane N, Sallam Tamer

机构信息

David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Division of Computational Biomedicine, Biological Chemistry, UCI, Irvine, California, USA.

出版信息

J Clin Invest. 2024 Sep 3;134(17):e179752. doi: 10.1172/JCI179752.

DOI:10.1172/JCI179752
PMID:39058558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11364399/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/649d/11364399/faf24342bb53/jci-134-179752-g048.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/649d/11364399/faf24342bb53/jci-134-179752-g048.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/649d/11364399/faf24342bb53/jci-134-179752-g048.jpg

相似文献

1
Hepatic lipopolysaccharide binding protein partially uncouples inflammation from fibrosis in MAFLD.肝脏脂多糖结合蛋白在MAFLD中部分解除炎症与纤维化之间的关联。
J Clin Invest. 2024 Sep 3;134(17):e179752. doi: 10.1172/JCI179752.
2
Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels.衰老相关的肝退化与细菌内毒素和脂多糖结合蛋白水平升高有关。
Am J Physiol Gastrointest Liver Physiol. 2020 Apr 1;318(4):G736-G747. doi: 10.1152/ajpgi.00345.2018. Epub 2020 Feb 24.
3
Hepatic toll-like receptor 4 expression is associated with portal inflammation and fibrosis in patients with NAFLD.肝组织 Toll 样受体 4 的表达与非酒精性脂肪性肝病患者的门脉炎症和纤维化相关。
Liver Int. 2015 Feb;35(2):569-81. doi: 10.1111/liv.12531. Epub 2014 Apr 5.
4
Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity.脂多糖结合蛋白（Lbp）在肝脏中的表达受肠道菌群通过 Myd88 诱导，且独立于肥胖，会损害小鼠的葡萄糖耐量。
Mol Metab. 2020 Jul;37:100997. doi: 10.1016/j.molmet.2020.100997. Epub 2020 Apr 16.
5
Toll-like receptor 4 and hepatic fibrogenesis. toll 样受体 4 与肝纤维化。
Semin Liver Dis. 2010 Aug;30(3):232-44. doi: 10.1055/s-0030-1255353. Epub 2010 Jul 21.
6
Attenuated antigen-specific T cell responses in cirrhosis are accompanied by elevated serum interleukin-10 levels and down-regulation of HLA-DR on monocytes.肝硬化患者的抗原特异性 T 细胞反应减弱，同时伴有血清白细胞介素-10 水平升高和单核细胞 HLA-DR 下调。
BMC Gastroenterol. 2013 Feb 27;13:37. doi: 10.1186/1471-230X-13-37.
7
LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction.脂多糖结合蛋白在胆道梗阻情况下介导脂多糖诱导的肝损伤和死亡。
Am J Physiol Gastrointest Liver Physiol. 2009 Jan;296(1):G45-54. doi: 10.1152/ajpgi.00041.2008. Epub 2008 Oct 23.
8
Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice.脂多糖结合蛋白调节对乙酰氨基酚诱导的小鼠肝损伤。
Hepatology. 2005 Jan;41(1):187-95. doi: 10.1002/hep.20533.
9
A standardized aqueous extract of Anoectochilus formosanus ameliorated thioacetamide-induced liver fibrosis in mice: the role of Kupffer cells.台湾金线莲标准化水提取物改善硫代乙酰胺诱导的小鼠肝纤维化：库普弗细胞的作用
Biosci Biotechnol Biochem. 2010;74(4):781-7. doi: 10.1271/bbb.90824. Epub 2010 Apr 7.
10
Role of Autophagy in Chronic Liver Inflammation and Fibrosis.自噬在慢性肝脏炎症和纤维化中的作用。
Curr Protein Pept Sci. 2019;20(8):817-822. doi: 10.2174/1389203720666190305165203.

引用本文的文献

1
Unraveling the Metabolic Pathways Between Metabolic-Associated Fatty Liver Disease (MAFLD) and Sarcopenia.解析代谢相关脂肪性肝病（MAFLD）与肌肉减少症之间的代谢途径
Int J Mol Sci. 2025 May 14;26(10):4673. doi: 10.3390/ijms26104673.
2
Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols.代谢相关脂肪性肝病：氧化应激、炎症、线粒体功能障碍的影响及多酚的作用
Pharmaceuticals (Basel). 2024 Oct 10;17(10):1354. doi: 10.3390/ph17101354.

本文引用的文献

1
Cenicriviroc Lacked Efficacy to Treat Liver Fibrosis in Nonalcoholic Steatohepatitis: AURORA Phase III Randomized Study.西尼riviroc 治疗非酒精性脂肪性肝炎肝纤维化的疗效缺失：AURORA 三期随机研究。
Clin Gastroenterol Hepatol. 2024 Jan;22(1):124-134.e1. doi: 10.1016/j.cgh.2023.04.003. Epub 2023 Apr 13.
2
Liver inflammation and fibrosis.肝脏炎症和纤维化。
J Clin Invest. 2017 Jan 3;127(1):55-64. doi: 10.1172/JCI88881.
3
The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis.巨噬细胞脂多糖结合蛋白（LBP）基因是肝脏X受体（LXR）的一个靶点，可促进巨噬细胞存活及动脉粥样硬化。
J Lipid Res. 2014 Jun;55(6):1120-30. doi: 10.1194/jlr.M047548. Epub 2014 Mar 26.
4
Structure and function of lipopolysaccharide binding protein.脂多糖结合蛋白的结构与功能
Science. 1990 Sep 21;249(4975):1429-31. doi: 10.1126/science.2402637.