Gnyawali Krishna Prasad, Shakenov Aldiyar, Kirinde Arachchige Pandula T, Yi Chae S
Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53233, United States.
J Org Chem. 2024 Aug 16;89(16):11119-11135. doi: 10.1021/acs.joc.4c00063. Epub 2024 Jul 26.
The catalytic system generated from the cationic Ru-H complex [(CH)(PCy)(CO)RuH]BF () with 2,3,4,5-tetrachloro-1,2-benzoquinone () was found to be highly effective for promoting the deaminative coupling reaction of 2-aminoaryl aldehydes with branched amines to form 2-substituted quinoline products. The analogous deaminative coupling reaction of 2-aminoaryl ketones with branched amines led to the regioselective formation of 2,4-disubstituted quinoline products. A number of biologically active quinoline derivatives including graveolinine and a triplex DNA intercalator have been synthesized by using the catalytic method.
由阳离子钌氢配合物[(CH)(PCy)(CO)RuH]BF（）与2,3,4,5-四氯-1,2-苯醌（）生成的催化体系被发现对促进2-氨基芳基醛与支链胺的脱氨基偶联反应以形成2-取代喹啉产物非常有效。2-氨基芳基酮与支链胺的类似脱氨基偶联反应导致区域选择性地形成2,4-二取代喹啉产物。通过使用该催化方法已经合成了许多具有生物活性的喹啉衍生物，包括graveolinine和一种三链DNA嵌入剂。
