人类糖组图谱计划旨在编目人类所有与聚糖相关的组学数据。
The Human Glycome Atlas project for cataloging all glycan-related omics data in human.
作者信息
Aoki-Kinoshita Kiyoko F, Akune-Taylor Yukie, Ando Hiromune, Angata Kiyohiko, Fujita Morihisa, Furukawa Jun-Ichi, Kaji Hiroyuki, Kato Koichi, Kitajima Ken, Kizuka Yasuhiko, Matsui Yusuke, Nakajima Kazuki, Nishihara Shoko, Okajima Tetsuya, Sakamoto Kazuma, Sato Chihiro, Thaysen-Andersen Morten, Togayachi Akira, Yagi Hirokazu, Zappa Achille, Kadomatsu Kenji
机构信息
GaLSIC, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo, 192-8577, Japan.
iGCORE, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
出版信息
Glycobiology. 2024 Sep 30;34(11). doi: 10.1093/glycob/cwae052.
The Human Glycome Atlas (HGA) Project was launched in April 2023, spearheaded by three Japanese institutes: the Tokai National Higher Education and Research System, the National Institutes of Natural Sciences, and Soka University. This was the first time that a field in the life sciences was adopted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) for a Large-scale Academic Frontiers Promotion Project. This project aims to construct a knowledgebase of human glycans and glycoproteins as a standard for the human glycome. A high-throughput pipeline for comprehensively analyzing 20,000 blood samples in its first five years is planned, at which time an access-controlled version of a human glycomics knowledgebase, called TOHSA, will be released. By the end of the final tenth year, TOHSA will provide a central resource linking human glycan data with other omics data including disease-related information.
人类糖组图谱（HGA）项目于2023年4月启动，由三个日本机构牵头：东海国立高等教育与研究系统、国立自然科学研究所和创价大学。这是文部科学省（MEXT）首次将生命科学领域纳入大规模学术前沿推进项目。该项目旨在构建人类聚糖和糖蛋白知识库，作为人类糖组的标准。计划在前五年建立一个高通量流程，用于全面分析20000份血样，届时将发布一个名为TOHSA的人类糖组学知识库的访问受限版本。到第十年结束时，TOHSA将提供一个核心资源，将人类聚糖数据与包括疾病相关信息在内的其他组学数据联系起来。
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