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聚糖图谱工具,用于可视化和查询聚糖数据。

The GlycomeAtlas tool for visualizing and querying glycome data.

机构信息

Department of Bioinformatics, Faculty of Engineering, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo 192-8577, Japan.

出版信息

Bioinformatics. 2012 Nov 1;28(21):2849-50. doi: 10.1093/bioinformatics/bts516. Epub 2012 Aug 24.

Abstract

MOTIVATION

The development of glycomics technologies in recent years has produced a sufficient amount of data to begin analyzing the glycan structures present in various organisms and tissues. In particular, glycan profiling using mass spectrometry (MS) and tandem MS has generated a large amount of data that are waiting to be analyzed. The Consortium for Functional Glycomics (CFG) has provided a web resource for obtaining such glycan profiling data easily. Although an interactive spectrum viewer is provided on the website as a Java applet, it is not necessarily easy to search for particular glycans or to find commonalities between different tissues in a single organism, for example. Therefore, to allow users to better take advantage of the valuable glycome data that can be obtained from mass spectra and other leading technologies, we have developed a tool called Glycome Atlas which is pre-loaded with the data from the CFG and is also able to visualize local glycan profiling data for human and mouse.

RESULTS

We have developed a tool to allow users to visualize and perform queries of glycome data. This tool, called GlycomeAtlas, is pre-loaded with glycome data as provided by the CFG. Moreover, users can load their own local glycome data into this tool to visualize and perform queries on their own data.

AVAILABILITY

This tool is available at the following URL: http://www.rings.t.soka.ac.jp/GlycomeAtlas/GUI.html.

摘要

动机

近年来糖组学技术的发展产生了足够多的数据,从而可以开始分析各种生物体和组织中存在的聚糖结构。特别是,使用质谱(MS)和串联 MS 进行聚糖分析已经产生了大量等待分析的数据。功能糖组学联合会(CFG)提供了一个网络资源,以便轻松获取此类聚糖分析数据。尽管网站上提供了一个交互式光谱查看器作为 Java 小程序,但搜索特定聚糖或在单个生物体的不同组织之间找到共性并不一定容易。因此,为了使用户能够更好地利用从质谱和其他领先技术获得的有价值的糖组数据,我们开发了一种名为 GlycomeAtlas 的工具,它预先加载了 CFG 的数据,并且还能够可视化人类和小鼠的局部糖组分析数据。

结果

我们开发了一种工具,使用户能够可视化和查询糖组数据。该工具称为 GlycomeAtlas,它预先加载了 CFG 提供的糖组数据。此外,用户可以将自己的本地糖组数据加载到此工具中,以可视化和查询自己的数据。

可用性

该工具可在以下网址获得:http://www.rings.t.soka.ac.jp/GlycomeAtlas/GUI.html。

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