用于植物的优化dCas9可编程转录激活剂。 - Suppr

Optimized dCas9 programmable transcriptional activators for plants.

作者信息

Zinselmeier Matthew H, Casas-Mollano Juan Armando, Cors Jonathan, Sychla Adam, Heinsch Stephen C, Voytas Daniel F, Smanski Michael J

机构信息

Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.

Center for Precision Plant Genomics, Saint Paul, MN, USA.

出版信息

Plant Biotechnol J. 2024 Nov;22(11):3202-3204. doi: 10.1111/pbi.14441. Epub 2024 Jul 26.

DOI:10.1111/pbi.14441

PMID:39058765

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11495988/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b667/11500979/5ef59fa31cbd/PBI-22-3202-g001.jpg

相似文献

Optimized dCas9 programmable transcriptional activators for plants.

Plant Biotechnol J. 2024 Nov;22(11):3202-3204. doi: 10.1111/pbi.14441. Epub 2024 Jul 26.

Targeted Modulation of Chicken Genes In Vitro Using CRISPRa and CRISPRi Toolkit.

Genes (Basel). 2023 Apr 13;14(4):906. doi: 10.3390/genes14040906.

Recent Progress and Future Prospect of CRISPR/Cas-Derived Transcription Activation (CRISPRa) System in Plants.

Cells. 2022 Sep 28;11(19):3045. doi: 10.3390/cells11193045.

Highly efficient activation of endogenous gene in grape using CRISPR/dCas9-based transcriptional activators.

Hortic Res. 2022 Jan 18;9. doi: 10.1093/hr/uhab037.

RNA-guided transcriptional regulation in planta via synthetic dCas9-based transcription factors.

Plant Biotechnol J. 2015 May;13(4):578-89. doi: 10.1111/pbi.12284. Epub 2014 Nov 14.

Programmable CRISPR-Cas transcriptional activation in bacteria.

Mol Syst Biol. 2020 Jul;16(7):e9427. doi: 10.15252/msb.20199427.

Improved drought stress tolerance in Arabidopsis by CRISPR/dCas9 fusion with a Histone AcetylTransferase.

Sci Rep. 2019 May 30;9(1):8080. doi: 10.1038/s41598-019-44571-y.

Mini and enhanced CRISPR activators for cancer therapies.

J Adv Res. 2024 Nov 3. doi: 10.1016/j.jare.2024.10.027.

CRISPR-Act3.0 for highly efficient multiplexed gene activation in plants.

Nat Plants. 2021 Jul;7(7):942-953. doi: 10.1038/s41477-021-00953-7. Epub 2021 Jun 24.

A potent Cas9-derived gene activator for plant and mammalian cells.

Nat Plants. 2017 Dec;3(12):930-936. doi: 10.1038/s41477-017-0046-0. Epub 2017 Nov 20.

引用本文的文献

Efficient, cell-type-specific production of flavonols by multiplexed CRISPR activation of a suite of metabolic enzymes.

Nat Commun. 2025 Jul 16;16(1):6559. doi: 10.1038/s41467-025-61742-w.

Epigenome Engineering Using dCas Systems for Biomedical Applications and Biotechnology: Current Achievements, Opportunities and Challenges.

Int J Mol Sci. 2025 Jul 2;26(13):6371. doi: 10.3390/ijms26136371.

Towards engineering hybrid incompatibility in plants.

Plant Biotechnol J. 2025 Jul;23(7):2752-2754. doi: 10.1111/pbi.70096. Epub 2025 Apr 22.

A Truncated Endogenous U6 Promoter Enables High-Efficiency CRISPR Editing in Flax ( L.).

Plants (Basel). 2025 Apr 6;14(7):1142. doi: 10.3390/plants14071142.

Efficient gene activation in plants by the MoonTag programmable transcriptional activator.

Nucleic Acids Res. 2023 Jul 21;51(13):7083-7093. doi: 10.1093/nar/gkad458.

Efficient gene activation in plants by the MoonTag programmable transcriptional activator.

bioRxiv. 2023 Feb 15:2023.02.15.528671. doi: 10.1101/2023.02.15.528671.

本文引用的文献

Efficient gene activation in plants by the MoonTag programmable transcriptional activator.

Nucleic Acids Res. 2023 Jul 21;51(13):7083-7093. doi: 10.1093/nar/gkad458.

Characterization of Programmable Transcription Activators in the Model Monocot Setaria viridis Via Protoplast Transfection.

Methods Mol Biol. 2022;2464:223-244. doi: 10.1007/978-1-0716-2164-6_16.

CRISPR-Act3.0 for highly efficient multiplexed gene activation in plants.

Nat Plants. 2021 Jul;7(7):942-953. doi: 10.1038/s41477-021-00953-7. Epub 2021 Jun 24.

CRISPR-Cas Activators for Engineering Gene Expression in Higher Eukaryotes.

CRISPR J. 2020 Oct;3(5):350-364. doi: 10.1089/crispr.2020.0064.

Engineering multiple species-like genetic incompatibilities in insects.

Nat Commun. 2020 Sep 8;11(1):4468. doi: 10.1038/s41467-020-18348-1.

Widespread long-range cis-regulatory elements in the maize genome.

Nat Plants. 2019 Dec;5(12):1237-1249. doi: 10.1038/s41477-019-0547-0. Epub 2019 Nov 18.

Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems.

Nat Commun. 2019 Feb 13;10(1):729. doi: 10.1038/s41467-019-08736-7.

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.

Cell. 2018 Dec 13;175(7):1842-1855.e16. doi: 10.1016/j.cell.2018.10.042. Epub 2018 Nov 15.

Robust Transcriptional Activation in Plants Using Multiplexed CRISPR-Act2.0 and mTALE-Act Systems.

Mol Plant. 2018 Feb 5;11(2):245-256. doi: 10.1016/j.molp.2017.11.010. Epub 2017 Nov 29.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Optimized dCas9 programmable transcriptional activators for plants.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献