Department of Pathology, Guangzhou Red Cross Hospital affiliated to Jinan University Guangzhou, Guangdong Province, China.
Department of Breast Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong, China.
Medicine (Baltimore). 2024 Jul 26;103(30):e39131. doi: 10.1097/MD.0000000000039131.
Breast low-grade adenosquamous carcinoma is an uncommon cancer that has been neglected in genetic and pathophysiological research. Consequently, medical practitioners face challenges in the effective diagnosis and treatment of this condition.
We present the case of a 57-year-old Asian female patient who presented with bilateral breast masses on physical examination. Ultrasound and an MRI revealed a highly suspicious malignant mass in her right breast that was completely removed surgically.
After pathological analysis, the diagnosis was low-grade adenosquamous carcinoma with local high-grade transformation, and some of the tumor components were estrogen receptor positive.
The patient underwent appropriate postoperative chemotherapy and achieved a favorable outcome.
During the follow-up period after surgical resection, the patient did not experience any local recurrence or distant metastasis.
Owing to the rare combination of estrogen receptor positivity and high-grade progression, this patient also required adjuvant chemotherapy. This enhances the essential foundation for diagnosing and treating this rare disease, and facilitates the implementation of treatment plans.
乳腺低度涎腺鳞状细胞癌是一种罕见的癌症，在遗传和病理生理学研究中被忽视。因此，临床医生在有效诊断和治疗这种疾病方面面临挑战。
我们报告了一例 57 岁亚洲女性患者，其在体格检查时发现双侧乳腺肿块。超声和 MRI 显示其右侧乳腺有一个高度怀疑为恶性的肿块，该肿块已通过手术完全切除。
经病理分析，诊断为低度涎腺鳞状细胞癌伴局部高级别转化，部分肿瘤成分呈雌激素受体阳性。
患者接受了适当的术后化疗，治疗效果良好。
在手术切除后的随访期间，患者未出现局部复发或远处转移。
由于雌激素受体阳性和高级别进展的罕见组合，该患者还需要辅助化疗。这为诊断和治疗这种罕见疾病提供了重要基础，并有助于实施治疗计划。
