Department of Respiratory Medicine, Osaka General Medical Center, Osaka, Japan.
Medicine (Baltimore). 2024 Jul 26;103(30):e39094. doi: 10.1097/MD.0000000000039094.
Extracorporeal membrane oxygenation (ECMO) is the last trump card for severe respiratory failure. The main complications of ECMO are bleeding and thrombosis, both of which can be life-threatening. Large blood clots can cause central airway obstruction (CAO) during ECMO, and CAO should be removed as soon as possible because of asphyxiation. However, there is no comprehensive reports on its frequency and management. The purpose of this study is to share therapeutic experiences for rare and serious conditions and provide valuable insights.
We report 3 patients placed on ECMO for severe respiratory failure.
CAO due to large blood clots occurred during ECMO in all 3 patients.
Large blood clots were removed using flexible bronchoscopy, grasping forceps, and net retrieval devices in all 3 patients.
In all 3 patients, large blood clots were removed multiple times during ECMO. The patients' respiratory conditions improved and they were eventually weaned off the ECMO.
CAO due to large blood clots during ECMO is rare. The frequency of CAO requiring bronchoscopic removal was estimated to be approximately 1,5%. When this occurs, clots should be removed as soon as possible. Net retrieval devices are useful tools for the collection of large blood clots.
体外膜肺氧合(ECMO)是严重呼吸衰竭的最后手段。ECMO 的主要并发症是出血和血栓形成,两者都可能危及生命。大量血栓在 ECMO 期间可导致中央气道阻塞(CAO),因为有窒息的风险,CAO 应尽快清除。然而,目前还没有关于其频率和管理的综合报告。本研究旨在分享治疗罕见和严重疾病的经验,并提供有价值的见解。
我们报告了 3 例因严重呼吸衰竭而接受 ECMO 治疗的患者。
所有 3 例患者在 ECMO 期间均发生由大血块引起的 CAO。
所有 3 例患者均通过柔性支气管镜、抓钳和网兜取栓装置清除了大血块。
在所有 3 例患者中,在 ECMO 期间多次清除大血块。患者的呼吸状况改善,最终成功撤离 ECMO。
ECMO 期间由于大血块引起的 CAO 很少见。需要支气管镜清除的 CAO 发生率估计约为 1.5%。发生这种情况时,应尽快清除血栓。网兜取栓装置是收集大血块的有用工具。