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基于聚多巴胺纳米颗粒的联合化疗与光热疗法治疗肝癌

Polydopamine Nanoparticle-Based Combined Chemotherapy and Photothermal Therapy for the Treatment of Liver Cancer.

作者信息

Emanet Melis, Lefevre Marie Celine, Ceccarelli Maria Cristina, Battaglini Matteo, Carmignani Alessio, Schiavone Francesco, Marino Attilio, De Pasquale Daniele, Prato Mirko, De Boni Francesco, Petretto Andrea, Bartolucci Martina, Catalano Federico, Moscato Stefania, Ciofani Gianni

机构信息

Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.

The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.

出版信息

ACS Appl Mater Interfaces. 2024 Aug 7;16(31):40695-40713. doi: 10.1021/acsami.4c08491. Epub 2024 Jul 26.

DOI:10.1021/acsami.4c08491
PMID:39058979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11310915/
Abstract

Polydopamine nanoparticles (PDA NPs) are proposed as an anti-cancer tool against hepatocellular carcinoma through the combination of near-infrared (NIR)-mediated hyperthermia and loading with a chemotherapeutic drug, sorafenib (SRF). Cell membranes isolated from a liver cancer cell line (HepG2) have been exploited for the coating of the nanoparticles (thus obtaining CM-SRF-PDA NPs), to promote homotypic targeting toward cancer cells. The selective targeting ability and the combined photothermal and chemotherapeutic activity of the CM-SRF-PDA NPs following NIR irradiation have been evaluated on cell cultures in static and dynamic conditions, besides three-dimensional culture models. Eventually, the therapeutic effectiveness of the proposed approach has also been tested on HepG2 spheroid-grafted quail embryos. This comprehensive investigation, supported by proteomic analysis, showed the effectiveness of the proposed nanoplatform and strongly suggests further pre-clinical testing in the treatment of liver cancer.

摘要

聚多巴胺纳米颗粒（PDA NPs）被提议作为一种针对肝细胞癌的抗癌工具，通过近红外（NIR）介导的热疗与化疗药物索拉非尼（SRF）负载相结合来实现。从肝癌细胞系（HepG2）分离的细胞膜已被用于纳米颗粒的包覆（从而获得CM-SRF-PDA NPs），以促进对癌细胞的同型靶向。除了三维培养模型外，还在静态和动态条件下的细胞培养中评估了CM-SRF-PDA NPs在近红外照射后的选择性靶向能力以及联合光热和化疗活性。最终，所提出方法的治疗效果也在接种了HepG2球体的鹌鹑胚胎上进行了测试。这项由蛋白质组学分析支持的全面研究表明了所提出的纳米平台的有效性，并强烈建议在肝癌治疗中进行进一步的临床前测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/465e2aa74732/am4c08491_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/a6908f50443b/am4c08491_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/685af8a6b80f/am4c08491_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/7f014445b870/am4c08491_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/20988ad24d7d/am4c08491_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/fd180fa60b63/am4c08491_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/7a75dadb00c5/am4c08491_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/02c6caf92a15/am4c08491_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/465e2aa74732/am4c08491_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/a6908f50443b/am4c08491_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/685af8a6b80f/am4c08491_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/7f014445b870/am4c08491_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/20988ad24d7d/am4c08491_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/fd180fa60b63/am4c08491_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/7a75dadb00c5/am4c08491_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/02c6caf92a15/am4c08491_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e94/11310915/465e2aa74732/am4c08491_0008.jpg

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Polydopamine Nanoparticle-Based Combined Chemotherapy and Photothermal Therapy for the Treatment of Liver Cancer.

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引用本文的文献

[1]
Material-Driven Therapeutics: Functional Nanomaterial Design Paradigms Revolutionizing Osteosarcoma Treatment.

J Funct Biomater. 2025-6-5

[2]
Assessment of CuFeSe ternary nanozymes for multimodal triple negative breast cancer theranostics.

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本文引用的文献

[1]
Hepatocellular Carcinoma cells: activity of Amygdalin and Sorafenib in Targeting AMPK /mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death.

BMC Complement Med Ther. 2023-9-19

[2]
A Novel Patient-Personalized Nanovector Based on Homotypic Recognition and Magnetic Hyperthermia for an Efficient Treatment of Glioblastoma Multiforme.

Adv Healthc Mater. 2023-7

[3]
New insights in polydopamine formation via surface adsorption.

Nat Commun. 2023-2-7

[4]
Curcumin- and resveratrol-co-loaded nanoparticles in synergistic treatment of hepatocellular carcinoma.

J Nanobiotechnology. 2022-7-20

[5]
Adverse events of sorafenib in hepatocellular carcinoma treatment.

Am J Cancer Res. 2022-6-15

[6]
Sorafenib-loaded silica-containing redox nanoparticles for oral anti-liver fibrosis therapy.

J Control Release. 2022-5

[7]
Measuring the density and viscosity of culture media for optimized computational fluid dynamics analysis of in vitro devices.

J Mech Behav Biomed Mater. 2022-2

[8]
Microtechnology-based models: Mimicking liver function and pathophysiology.

APL Bioeng. 2021-10-15

[9]
Magnetic implants in vivo guiding sorafenib liver delivery by superparamagnetic solid lipid nanoparticles.

J Colloid Interface Sci. 2022-2-15

[10]
PRMT1 promotes the tumor suppressor function of p14 and is indicative for pancreatic cancer prognosis.

EMBO J. 2021-7-1

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