光遗传学调节心脏自主神经系统。
Optogenetic modulation of cardiac autonomic nervous system.
机构信息
Electrocardiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1 Belisario Domínguez secc. 16 Tlalpan CP 14080, Mexico City, Mexico; Surgery Department, Hospital Regional de Alta Especialidad Dr. Juan Graham Casasús, Calle Uno S/N, Miguel Hidalgo III Etapa, Villahermosa, 86126, Tabasco, Mexico.
Electrocardiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1 Belisario Domínguez secc. 16 Tlalpan CP 14080, Mexico City, Mexico.
出版信息
Auton Neurosci. 2024 Oct;255:103199. doi: 10.1016/j.autneu.2024.103199. Epub 2024 Jul 17.
The following is a narrative review of the fundamentals of optogenetics. It focuses on the advantages and constraints of manipulating the autonomic nervous system by modifying the pathophysiological characteristics that arise in different diseases. Although the use of this technique is currently experimental, we will discuss improvements that have been implemented and identify the necessary measures for potential preclinical translation in the control of the cardiac autonomic nervous system.
以下是一篇关于光遗传学基础的叙述性综述。它侧重于通过改变不同疾病中出现的病理生理特征来操纵自主神经系统的优势和限制。尽管目前这项技术的应用尚处于实验阶段，但我们将讨论已经实施的改进，并确定在控制心脏自主神经系统方面进行潜在临床前转化所需的措施。
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