Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
Aging Dis. 2024 Aug 1;15(4):1432-1437. doi: 10.14336/AD.2023.1719.
Vascular pathologies are among the most common contributors to neurodegenerative changes across the spectrum of normal aging to dementia. Cerebral small vessel disease (SVD) encompasses a wide range of conditions affecting capillaries, small arteries, and arterioles, as well as perivascular spaces and fluid dynamics in the brain, playing a significant role in vascular contributions to cognitive impairment and dementia (VCID). These factors can accelerate the progression of SVD and neuronal degeneration. Since aging is the primary risk factor for Alzheimer's disease (AD) and AD-related dementias (ADRD), this Research Topic aims to gather recent research to better understand vascular contributions to healthy aging and age-related cognitive impairment. Other risk factors include diabetes, lifestyle factors, high cholesterol, vascular inflammation, and immune remodeling, all of which can accelerate cognitive dysfunction progression. This special issue includes a total of 21 articles comprising Reviews, Perspectives, and Original Research articles. The articles cover various technical and biological aspects related to recent progress in aging and dementia research. We aim to promote research exchange across different fields, including imaging, VCID, molecular biology, neuroinflammation, and immunology. Most papers in this special issue focus on understanding the disease mechanisms of AD/ADRD and developing new therapeutic strategies.
血管病理学是导致从正常衰老到痴呆的神经退行性变化的最常见原因之一。脑小血管病 (SVD) 涵盖了一系列影响毛细血管、小动脉和小动脉以及血管周围间隙和大脑内流体动力学的疾病，在血管性认知障碍和痴呆 (VCID) 中起着重要作用。这些因素会加速 SVD 和神经元变性的进展。由于衰老是阿尔茨海默病 (AD) 和 AD 相关痴呆 (ADRD) 的主要危险因素，本研究专题旨在汇集最新研究成果，以更好地了解血管对健康衰老和与年龄相关的认知障碍的贡献。其他危险因素包括糖尿病、生活方式因素、高胆固醇、血管炎症和免疫重塑，所有这些因素都可能加速认知功能障碍的进展。本特刊共收录了 21 篇文章，包括综述、观点和原创研究文章。这些文章涵盖了与衰老和痴呆研究的最新进展相关的各种技术和生物学方面。我们的目标是促进不同领域的研究交流，包括影像学、VCID、分子生物学、神经炎症和免疫学。本特刊中的大多数论文都侧重于了解 AD/ADRD 的疾病机制并开发新的治疗策略。
