Institute of The Songshan Lake Central Hospital of Dongguan City, Dongguan 523326, China.
Institute of Maternal, Child and Adolescent Health, School of Public Health, Lanzhou University, Lanzhou 730000, China.
J Steroid Biochem Mol Biol. 2024 Nov;244:106591. doi: 10.1016/j.jsbmb.2024.106591. Epub 2024 Jul 24.
Steroid hormone imbalance is believed to increase the odds of developing PE. Bisphenol A (BPA) and its substitutes (e.g., bisphenol S (BPS) and bisphenol F (BPF)) have estrogen-like effects, and its exposure may be related to the development of preeclampsia (PE). To explore the effects of bisphenol exposure on maternal serum steroid hormones and the potential mediating role of steroid hormones in the association between bisphenol exposure and developing PE, concentrations of bisphenols and steroid hormones in serum samples of 383 pregnant women were examined before delivery (including 160 PE cases and 223 control cases). Multivariable logistic and linear models were used to explore the associations of maternal serum bisphenols concentrations with both maternal steroid hormones and PE risk. Mediation modeling was employed to evaluate the mediating role of steroid hormones in the association between bisphenols and PE. Results showed that maternal serum BPS concentrations were positively associated with testosterone (T) concentrations. The mediation analyses suggested that approximately 10.17 % of the associations between BPS concentrations and the development of PE might be mediated by maternal T. In conclusion, maternal exposure to BPS during pregnancy is linked to higher maternal T concentrations, which might increase the odds of developing PE. T might mediate the association between BPS exposure and the development of PE.
类固醇激素失衡被认为会增加发生 PE 的几率。双酚 A（BPA）及其替代品（如双酚 S（BPS）和双酚 F（BPF））具有雌激素样作用，其暴露可能与先兆子痫（PE）的发生有关。为了探讨双酚暴露对母体血清类固醇激素的影响，以及类固醇激素在双酚暴露与发生 PE 之间的关联中的潜在中介作用，在分娩前检查了 383 名孕妇血清样本中的双酚和类固醇激素浓度（包括 160 例 PE 病例和 223 例对照病例）。多变量逻辑和线性模型用于探讨母体血清双酚浓度与母体类固醇激素和 PE 风险之间的关系。中介模型用于评估类固醇激素在双酚与 PE 之间的关联中的中介作用。结果表明，母体血清 BPS 浓度与睾酮（T）浓度呈正相关。中介分析表明，BPS 浓度与 PE 发生之间的关联中，约有 10.17%可能是由母体 T 介导的。总之，孕妇在怀孕期间接触 BPS 与较高的母体 T 浓度有关，这可能会增加发生 PE 的几率。T 可能介导了 BPS 暴露与 PE 发生之间的关联。
