Directors' Unit, EMBL-Heidelberg, Meyerhofstr. 1, 69117, Heidelberg, Germany.
Directors' Unit, EMBL-Heidelberg, Meyerhofstr. 1, 69117, Heidelberg, Germany.
Dev Biol. 2024 Nov;515:129-138. doi: 10.1016/j.ydbio.2024.07.014. Epub 2024 Jul 24.
In this review we discuss how the mammalian interfollicular epidermis forms during development, maintains homeostasis, and is repaired following wounding. Recent studies have provided new insights into the relationship between the stem cell compartment and the differentiating cell layers; the ability of differentiated cells to dedifferentiate into stem cells; and the epigenetic memory of epidermal cells following wounding.
在这篇综述中,我们讨论了哺乳动物滤泡间表皮在发育过程中是如何形成的,如何维持其体内平衡,以及在受伤后如何进行修复。最近的研究为以下几个方面提供了新的见解:干细胞区室和分化细胞层之间的关系;分化细胞逆转为干细胞的能力;以及受伤后表皮细胞的表观遗传记忆。