Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil
Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil.
BMJ Open. 2024 Jul 25;14(7):e082112. doi: 10.1136/bmjopen-2023-082112.
One of the topics that show differences of opinion in the scientific field of nutrition is the recommendation by clinical practice guidelines (CPGs) of an immunomodulatory diet with arginine, nucleotides and omega-3 for individuals diagnosed with cancer undergoing major surgery. The quality of the recommendations is directly related to credibility, transparency and rigour in their development, but also to the quality of the studies published and available for inclusion in the recommendation, such as systematic reviews (SRs) and randomised clinical trials. The aim of this study is to evaluate the methodological quality of the recommendation of perioperative immunomodulatory supplementation for individuals with gastrointestinal and head and neck cancer, the CPGs, and the studies that support the recommendations.
We will conduct a systematic search for CPGs. Recommendations for nutritional supplementation with immunomodulatory substrates for individuals undergoing major oncological surgery will be analysed using the Appraisal of Guidelines Research and Evaluation-Recommendations Excellence tool. CPGs will be analysed using the Appraisal of Guidelines Research and Evaluation II tool. The SRs cited in the recommendations will be analysed using the A Measurement Tool to Assess Systematic Reviews II tool and additional questions regarding heterogeneity in reviews. The clinical trials cited in the SRs and in the guideline recommendations (when applicable) will be analysed according to questions regarding heterogeneity in trials. The results will be presented in tables or charts using descriptive analyses.
The results of this study will be disseminated through relevant conferences and peer-reviewed journals.
10.17605/OSF.IO/X2GYT.
在营养科学领域，有一个观点存在分歧，即临床实践指南（CPG）建议对接受重大手术的癌症患者采用富含精氨酸、核苷酸和 ω-3 的免疫调节饮食。建议的质量直接与其制定的可信度、透明度和严谨性相关，也与其发表的研究质量以及纳入建议的研究质量相关，例如系统评价（SR）和随机临床试验。本研究旨在评估胃肠道和头颈部癌症患者围手术期免疫调节补充的推荐建议、CPG 以及支持这些建议的研究的方法学质量。
我们将进行系统的 CPG 搜索。使用评估指南研究和评估-推荐卓越工具分析针对接受重大肿瘤手术的个体进行免疫调节底物营养补充的建议。使用评估指南研究和评估 II 工具分析 CPG。推荐中引用的 SR 将使用评估系统评价 II 工具和关于综述中异质性的附加问题进行分析。SR 中以及指南建议中（如果适用）引用的临床试验将根据关于试验中异质性的问题进行分析。结果将使用描述性分析以表格或图表形式呈现。
本研究的结果将通过相关会议和同行评议期刊进行传播。
10.17605/OSF.IO/X2GYT。
