College of Food Science and Engineering, Henan University of Technology, Zhengzhou, China.
College of Food Science and Engineering, Henan University of Technology, Zhengzhou, China.
Food Res Int. 2024 Sep;191:114682. doi: 10.1016/j.foodres.2024.114682. Epub 2024 Jun 27.
Dietary fiber (DF) is considered an interventional diet beneficial for human health. High DF intake effectively reduces the incidence of three major chronic diseases, type 2 diabetes (T2DM), cardiovascular disease (CVD), and colorectal cancer (CRC). The health benefits of DF are closely related to their physicochemical properties with major positive roles in human digestion and intestinal health. However, mechanisms linking DF with diseases remain unclear. The development of genomics, metabolomics, and immunology, and the powerful combination of animal models and clinical trials, have facilitated a better understanding of the relationships between DF and diseases. Accumulating evidence suggests that the physical existence of DF and DF-microbiota interaction are the key parameters controlling the action mechanisms of DF in chronic diseases. Therefore, this review discusses the potential mechanism of DF modulating T2DM, CVD, and CRC, therefore providing a theoretical basis for more effective use of DF to intervene in chronic diseases.
膳食纤维（DF）被认为是一种有益于人类健康的干预性饮食。高膳食纤维摄入能有效降低 2 型糖尿病（T2DM）、心血管疾病（CVD）和结直肠癌（CRC）这三种主要慢性病的发病率。DF 的健康益处与其理化性质密切相关，其在人类消化和肠道健康方面发挥着重要的积极作用。然而，DF 与疾病之间的联系机制尚不清楚。基因组学、代谢组学和免疫学的发展，以及动物模型和临床试验的有力结合，使我们能够更好地理解 DF 与疾病之间的关系。越来越多的证据表明，DF 的物理存在和 DF-微生物群相互作用是控制 DF 在慢性病中作用机制的关键参数。因此，本综述讨论了 DF 调节 T2DM、CVD 和 CRC 的潜在机制，为更有效地利用 DF 干预慢性病提供了理论依据。
